Decera Clinical Education Infectious Disease Podcast

In this episode, Jennifer Cocohoba, PharmD, AAHIVP, and David Koren, PharmD, MPH, AAHIVP, FIDSA, cover the most impactful LA ART and LA PrEP clinical studies presented at AIDS 2024, including: The PURPOSE 1 study of twice-yearly lenacapavir injections vs daily oral tenofovir as PrEP in cisgender women An open-label extension of HPTN 084 evaluating LA CAB safety during pregnancy 48-week data from t...

In this episode, Tristan J. Barber, MA, MD, FRCP, and Glenn J. Treisman, MD, PhD, discuss the importance of screening, diagnosing, and treating PTSD in people with HIV. They illustrate their discussion through a patient case and provide strategies for accomplishing this, sharing their own experiences and approaches to thinking about PTSD, structuring appointments, and integrating care.  Presenters...

In this episode, Colleen F. Kelley, MD, MPH, and Jemma Samitpol discuss key considerations to improve the patient experience among transgender persons with HIV, including:  Unique circumstances faced by transgender people trying to access HIV care (eg, stigma, discrimination) Best practices to improve access and linkage to HIV care Ways to integrate gender-affirming care into HIV care Creating a w...

In this episode featuring faculty from the United States and Europe, Aadia I. Rana, MD, and Laurence Slama, MD, PhD, discuss the subtleties of deciding among HIV treatment options in people with adherence challenges. Listen as they debate the potential risks and benefits of long-acting ART in this population, considerations for people with viremia or resistance, recommendations concerning proviral...

In this episode, Gregory Huhn, MD, MPHTM, presents a case study of a person with a long HIV treatment history, exploring when and how to consider agents with novel mechanisms of action. Listen as he discusses: The importance of engaging with patients to understand their perspectives and improve their satisfaction with their HIV care Options in people with multiclass resistance Studies of agents wi...

In this episode, Yvonne Gilleece, MB BCh, BAO, FRCP, uses a case study to illustrate why giving people space and time to engage in HIV care on their terms is key to overcoming potential shame and stigma. She discusses how people can be very vulnerable when engaging in HIV care, and trauma-informed care can help address these vulnerabilities in a safe, respectful way. Listen as she gives her perspe...

In this episode, George Lau, MD, FRCP (Edin, Lond), FHKAM (Med), FHKCP, FAASLD, MBBS (HKU), and a patient discuss opportunities to optimize care for people living with hepatitis B virus (HBV), including:  Consequences to poor adherence to antiviral therapy Strategies to promote medication adherence (eg, patient education, setting up routines) The role of routine monitoring to prevent complications...

In this episode, Gregory Huhn, MD, presents a case study exploring how to optimize oral ART for a person with a long history of different ART regimens. Listen as he discusses: Reasons to consider regimen optimization in the setting of viral suppression Evidence for INSTIs in the setting of resistance Data on when 2-drug regimens and long-acting regimens may or may not be good options Faculty ​Greg...

In this episode, Lucas Hill, PharmD, AAHIVP, BCACP, and Bernadette Jakeman, PharmD, PhC, BCPS, AAHIVP,discuss what pharmacists need to know to provide high-quality HIV care beyond viral suppression, including treatment strategies and tips for addressing and improving patients’ quality of life. Listen as they discuss: Reasons to consider regimen optimization in the setting of viral suppression Evid...

In this episode, Stuart C. Gordon, MD, FACP, FACG, AGAF, FAASLD; Marlyn J. Mayo, MD; and Brenda Remo discuss strategies for optimizing PBC pruritus care in the clinic setting. Listen to their conversation on how important it is to ask patients about their pruritus, validate their symptoms and feelings, and offer treatment options framed with realistic expectations. Presenters: Stuart C. Gordon, MD...

In this episode, Stuart C. Gordon, MD, FACP, FACG, AGAF, FAASLD; Marlyn J. Mayo, MD; and Brenda Remo discuss the patient experience with cholestatic pruritus in PBC. Listen to their conversation on how people describe the experience of cholestatic pruritus, the extent to which pruritus negatively affects quality of life, and the importance of educating healthcare professionals on this important sy...

In this episode, Bradley N. Gaynes, MD, MPH, and Glenn J. Treisman, MD, PhD, discuss the importance of screening, diagnosing, and treating depression in people living with HIV. They illustrate their discussion through a patient case and provide strategies for accomplishing this, including creation of a virtual network and employment of measurement-based care. Presenters: Bradley N. Gaynes, MD, MPH...

In this episode, Cristina Mussini, MD,and William R. Short, MD, MPH, FIDSA,discuss the potential role of ART in weight change among people living with HIV. Listen to their conversation on whether ART switch can lead to weight loss after weight gain and how to counsel people living with HIV on weight loss options, including lifestyle modifications and nonpharmacologic methods. Presenters Cristina M...

In this episode, Linda-Gail Bekker, MBChB, DTM&H, DCH, FCP(SA), PhD, uses a case study to illustrate why patients living with HIV may disengage with their care and how best to reengage them once they present at the clinic, including discussion of: The valid reasons patients have for disengaging with their HIV care Why the return to care should be celebrated How to support people living with HIV as...

In this second podcast of our series, hear expert faculty explore the CDC recommendations for mpox protection and discuss how vaccination can lead to immunologic equity. Topics include: Should we consider mpox an STI? What strategies can be used to improve mpox vaccination and overcome the challenges of vaccine implementation? Can mpox vaccine be coadministered with other vaccines? What is the int...

Hear expert faculty answer common questions about the risk, impact, and recommendations for protection against mpox, including: Why is mpox relevant to clinical practice? Who is at highest risk for mpox? How is mpox transmitted, and what are the clinical manifestations and complications of mpox infections? What are current ACIP recommendations for mpox vaccination? What about pre- and postexposure...

In this episode, Roger Bedimo, MD, MS, FACP, examines patient and regimen-based PrEP barriers and discusses practical interventions to support PrEP adherence in key populations. Topics covered include: Individual and community perspectives on PrEP barriers Key barriers by principal populations Strategies to support PrEP delivery PrEP options for key populations PrEP efficacy based on adherence in...

In this episode, Roger Bedimo, MD, MS, FACP, discusses strategies to overcome health disparities to improve PrEP uptake, including: Targeting key populations that would benefit from PrEP but have low rates of uptake, such as transgender women and people who inject drugs Addressing intersectionality Overcoming implicit bias Addressing PrEP inequity by geographic region Expanding PrEP uptake by expa...

In this episode, Roger Bedimo, MD, MS, FACP, examines provider-based and structural PrEP barriers and discusses practical methods for healthcare professionals to overcome these challenges. Topics covered include: Potential provider barriers to prescribing PrEP Strategies to facilitate conversations about PrEP Addressing the gap in PrEP provider training Structural barriers for PrEP coverage, such...

In this episode, Tristan J. Barber, MA, MD, FRCP, and Roger Bedimo, MD, MS, FACP, help you decide whether and how to modify ART in virologically suppressed individuals by critically appraising whether using newer agents may improve their treatment satisfaction. Listen to their conversation about their own approaches to evaluating whether each person living with HIV is taking the best ART regimen f...

In this episode, Jonathan Appelbaum, MD, FACP, AAHIVS, discusses the updated CDC guidance on how to monitor for HIV in people receiving PrEP, including: Rationale for why HIV monitoring differs for people receiving LA vs daily PrEP Description of LEVI syndrome How to transition a person from LA PrEP to HIV ART if they test positive for HIV  Presenter: Jonathan Appelbaum, MD, FACP, AAHIVS Laurie L....

In this episode, Jonathan Appelbaum, MD, FACP, AAHIVS, discusses the newest data supporting LA ART use in people with adherence challenges or viremia, including: The LATITUDE study, an open-label phase III study of LA CAB + RPV in people with a suboptimal response or nonadherence to oral ART Updates to the Ward 86 cohort, which showed 81% of patients with viral suppression on LA CAB + RPV at Week...

In this episode, Angela Branche, MD, FIDSA, and Jewel Mullen, MD, MPH, MPA, FACP, address commonly asked questions about the RSV vaccine, including: Considerations for vaccine eligibility Recommendations for pregnant persons Vaccine administration based on RSV seasonality Use of the vaccine in persons receiving immunosuppressive medications Safety data (eg, risk of serious adverse events) Natural...

In this episode, Jewel Mullen, MD, MPH, MPA, FACP, discusses strategies for implementing RSV vaccines into practice, with an emphasis on: Understanding the reasoning for Advisory Committee on Immunization Practices RSV vaccine recommendations  Factors that influence vaccine uptake and patient decision-making Considerations for patient and healthcare professional vaccine hesitancy  Building vaccine...

In this episode, Angela Branche, MD, FIDSA, explores the burden of RSV disease in older adults, including: RSV seasonality and disease burden Symptoms and complications of RSV infection Older age as a key risk factor for severe RSV disease and complications (eg, pneumonia, hospitalization) Comorbidities associated with increased risk of RSV hospitalization RSV hospitalization rates among different...