Clinical Chemistry Podcast

Association of Blood Eosinophil and Blood Neutrophil Counts with Asthma Exacerbations in the Copenhagen General Population Study 11.04.2017 5:41 ↓

 Asthma is a chronic inflammatory lung disease that affects an estimated 300 million people worldwide, including 25 million in the United States. There are currently no definitive diagnostic tests for asthma. Diagnosis is based on history and tests of respiratory function.

Molecular Portrait of Metastasis-Competent Circulating Tumor Cells in Colon Cancer Reveals the Crucial Role of Genes Regulating Energy Metabolism and DNA Repair 27.03.2017 10:32 ↓

Circulating tumor cells are fundamental to the concept of a liquid biopsy for cancer.  These cells are shed from the primary tumor and are carried in the blood to remote sites, potentially leading to metastasis formation.  Understanding more about this process is critical as tumor metastasis is a leading cause of cancer death.  Yet this is challenging as the number of circulating tumor cells in an...

Are THC Levels in Oral Fluids and Blood Plasma Comparable after Oral Ingestion of Edibles Containing Cannabis or THC? 13.03.2017 22:05 ↓

Cannabis and its products are the most widely used illicit drugs world-wide, with the majority of countries currently harboring consumers and producers. Medicalization and legalization of the drug...

Bone Turnover Markers in the Diagnosis and Monitoring 01.03.2017 12:21 ↓

Disorders of bone metabolism, most notably osteoporosis, are highly prevalent and predispose to fractures, causing high patient morbidity and mortality.

High Glycated Albumin and Mortality in Persons with Diabetes Mellitus on Hemodialysis 01.03.2017 7:50 ↓

Monitoring of glycemic control with hemoglobin A1c (A1c) in hemodialysis patients may be compromised by anemia and erythropoietin therapy.

Patient Consent and the Commercialization of Lab Data 17.02.2017 11:31 ↓

Every year, commercial testing labs earn millions of dollars from selling the anonymized results of blood, urine, tissue, and other tests with almost no public scrutiny or debate.2 Few outside the industry know anything about this trade, and lab workers are often in the dark as well.

Clinical Chemistry's Commitment to Education: Stronger than Ever 17.02.2017 7:30 ↓

In addition to focusing on the publication of cutting-edge scientific reports, Clinical Chemistry has shown a genuine commitment to education by devoting a substantial portion of its pages to educational articles since 2008.

Universal Haplotype-Based Noninvasive Prenatal Testing for Single Gene Diseases 26.01.2017 10:35 ↓

Researchers have developed approaches for the noninvasive prenatal testing of single gene diseases.

Diurnal Rhythm of Cardiac Troponin: Consequences for the Diagnosis of Acute Myocardial Infarction 26.01.2017 9:07 ↓

Interpretation of serial high-sensitivity cardiac troponin (hs-cTn) measurements for the diagnosis of acute myocardial infarction (AMI) assumes random fluctuation of hs-cTn around an individual's homeostatic set point.

Short-term variability of vitamin D-related biomarkers 17.01.2017 4:12 ↓

Quantifying the variability of biomarkers is important, as high within-person variability can lead to misclassification of individuals. Short-term variability of important markers of vitamin D metabolism is relatively unknown.

Trimethylamine N-oxide and Risk Stratification after Acute Myocardial Infarction 05.01.2017 5:41 ↓

Risk stratification in acute myocardial infarction (MI) remains a clinical challenge.

Myocardial Infarction Type 2 and Myocardial Injury 05.01.2017 19:59 ↓

The development and implementation of sensitive and high-sensitivity cardiac troponin assays has not only expedited the early ruling in and ruling out of acute myocardial infarction, but has also contributed to the identification of patients at risk for myocardial injury with necrosis, as confirmed by the presence of cardiac troponin concentrations above the 99th percentile.

Immediate Rule-Out of Acute Myocardial Infarction Using Electrocardiogram and Baseline High-Sensitivity Troponin I 05.01.2017 4:48 ↓

Serial measurements of high-sensitivity troponin are used to rule out acute myocardial infarction (AMI) with an assay specific cutoff at the 99th percentile.