Clinical Chemistry Podcast

Full-Size Cardiac Troponin I and Its Proteolytic Fragments in Blood of Patients with Acute Myocardial Infarction: Antibody Selection for Assay Development 19.07.2018 11:37 ↓

Cardiac troponins are recognized as the primary biomarkers used in the diagnosis of acute myocardial infarction.  These are commonly detected by immunoassays, which offer the wide availability and rapid results needed in clinical care scenarios to rule out myocardial infarction.  However, immunodetection methods can be limited when there is degradation of the target analyte, as is the case with ca...

Clinical Utility of Transcriptome Sequencing: Toward a Better Diagnosis for Mendelian Disorders 29.05.2018 11:23 ↓

The June 2018 issue of Clinical Chemistry published a Perspective article titled, "Clinical Utility of Transcriptome Sequencing: Towards a Better Diagnosis for Mendelian Disorders."  In it, the authors Drs. Sumant Chakravorty and Madhuri Hegde discussed the impact of findings by Cummings and colleagues, who have shown for the first time in 2017 the clinical utility of next generation sequencing ba...

Neurogranin as Cerebrospinal Fluid Biomarker for Alzheimer Disease: An Assay Comparison Study 29.05.2018 9:24 ↓

Dementia is a devastating disease with a huge global impact. Today, over 46 million people live with dementia worldwide. It is possible that promising treatments for Alzheimer's disease have failed thus far because treatment was started at a late stage of the disease process. So, early treatment could be beneficial, but how do you recognize a patient with Alzheimer's disease if he or she does not...

Clinical Evaluation of a Blood Assay to Diagnose Paucibacillary Tuberculosis via Bacterial Antigens 17.05.2018 11:54 ↓

Tuberculosis is a prevalent and potentially deadly infectious disease with a worldwide incidence of more than 10 million new cases each year, and in 2015 alone, 1.4 million deaths were attributed to TB.  Much of the world relies on microbiologic techniques to detect tuberculosis including smear microscopy and mycobacterial culture which has a very long sample to answer timeframe. Both methods also...

Clinical and Genomic Insights from Metastatic Cancers 10.05.2018 14:47 ↓

Metastatic or recurrent cancers are a common cause of death among cancer patients.  Genomic investigations of cancer over the past 10 years have led to tremendous advancement in the understanding of the underlying biology and in the development of targeted treatment options.  Much of the discovery has been focused on primary treatment-naive cancers, since biological specimens for genomic analysis...