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AlphaFold is an AI system developed by DeepMind that predicts a protein’s 3D structure from its amino acid sequence. It regularly achieves accuracy competitive with experiment, and is accelerating research in nearly every field of biology. Daniel and Chris delve into protein folding, and explore the implications of this revolutionary and hugely impactful application of AI.

We add episode chapters to the website, KubeSail sells a PiBox, Nima Badizadegan wants you to use one big server, Gergeloy Orosz details oncall compensation across the software industry, Greg Kogan isn't impressed with how swamped you are at work, a dashboard template built on Bootstrap & Charm releases a CLI tool for shell scripts.

Episode 500!!! And it has been a journey! Nearly 13 years ago we started this podcast and as of today (this episode) we've officially shipped our 500th episode. As a companion to this episode, Jerod and Adam shipped a special Backstage episode where they reflect on 500 episodes. And...not only has it been a journey for us, but it's also been a journey for our good friend Chris Coyier and CSS-Trick...

AngularJS creator Miško Hevery has a new web framework he wants to tell us about, but he's not pitching just another framework, but with different DX. He says that Qwik is a fundamental rethinking of how a web application should work. And he's here to convince Jerod & KBall that the implications of that are BIG.

This is Adam and Jerod's pre-show call before hooking up with Chris Coyier to record episode 500 of The Changelog. We've been doing these off and on for awhile now. We hang out for 30ish minutes before the show begins and ship that conversation as a bonus for our Changelog++ members. We're doing this one different. You don't hit a round number like this very often. So, here it is. A standalone Bac...

Our today's guest spent 4 days building a feature for his side project so that we could ship it together on Ship It!, while recording. The feature is called `rave` mode, and the context is Bass, an interpreted functional scripting language written in Go, riffing on the ideas of Kernel & Clojure. When the local build runs, you can now press `r` to synchronise the beats of your currently playing Spo...

Our award winning worthy survey game show is back, this time Mat Ryer hosts it live on stage at GopherCon Europe 2022! Go Time's Natalie Pistunovich joins forces with Ronna Steinberg & Robert Burke to battle it out with V Körbes, Tamir Bahar & Konrad Richie. Let's see who can better guess what the GopherCon Europe gophers had to say!

Every year Mozilla releases an Internet Health Report that combines research and stories exploring what it means for the internet to be healthy. This year's report is focused on AI. In this episode, Solana and Bridget from Mozilla join us to discuss the power dynamics of AI and the current state of AI worldwide. They highlight concerning trends in the application of this transformational technolog...

Oleksii Trekhleb has a new drawing app, Zach Leatherman did some markdown generator speed tests, Jorge Fioranelli built a framework for Engineering Managers, Crockford got interviewed on Evrone & Daniel Sieger wrote up his clean coding advice.

This week we're joined again by Ben Ubois and we're talking about RSS. Yes, RSS...the tech that never seems to die and yet so many of us rely on it daily. Ben is the creator of Feedbin, which is self-described as "a nice place to read on the web." Ben is also the maker of a new app on iOS for people who like podcasts. It's called Airshow and you can download it at airshow.fm. Ben catches us up on...

KBall and Juri dive deep into monorepos, their benefits and gotchas, and how Nx helps you improve the performance and maintainability of a monorepo setup.

Go 1.18 was a major release where we saw the introduction of generics into the language as well as other notables such as fuzzing and workspaces. With Go 1.19 slated to come out next month, one has to wonder what’s next. Are we in store to be blown away by new and major features like we saw in 1.18? Not exactly but there are still lots of improvements to be on the lookout for. Joining Mat & Johnny...

We know that many of you listen to this podcast while running 🏃‍♀️ or cycling 🚴‍♂️ Hey Dan! How many of you cycled to a conference? Gerhard knows a single person that cycled 764 miles for 8 days straight from Switzerland to Spain for this year's KubeCon EU. His name is Johann Gyger, a CNCF ambassador & a cloud consultant at Peak Scale. Johann is a cloud engineer at heart that is all in on sustai...

In this Fully-Connected episode, Chris and Daniel explore the geopolitics, economics, and power-brokering of artificial intelligence. What does control of AI mean for nations, corporations, and universities? What does control or access to AI mean for conflict and autonomy? The world is changing rapidly, and the rate of change is accelerating. Daniel and Chris look behind the curtain in the halls o...

Brandur thinks soft deletion probably isn't worth it, the orange website delivers a high quality discussion on data structures, Podge O'Brien drops satirical management advice, team pico delivers prose.sh, Mat Ryer shares his thoughts on estimations & Matt Rickard's thoughts on RSS have us thinking about it as well.

This week we're joined by On Freund, former VP of Engineering at WeWork and now co-founder & CEO of Wilco. WeWork you may have heard of, but Wilco maybe not (yet). We get into the details behind the tech and scaling of WeWork, comparisons of the fictional series on Apple TV+ called WeCrashed and how much of that is true. Then we move on to Wilco which is what has On's full attention right now. Wil...

What's this? A Frontend Feud! The ShopTalk guys return to defend their championship over Syntax against new contenders: Una and Adam from The CSS Podcast!

How do beginners learn Go? This episode is meant to engage both non-Go users that listen to sister podcasts here on Changelog, or any Go-curious programmers out there, as well as encourage those that have started to learn Go and want to level up beyond the basics. On this episode we're aiming to answer questions about how to learn Go, identify resources that are available, and where you can go to...

Gerhard's transition to a senior engineer started 10 years ago, when he embraced the vim mindset, functional core & imperative shell, and was inspired to seek simplicity in his code & infrastructure. Most of it can be traced back to one person: Gary Bernhardt, the creator of Execute Program, Destroy all Software and the now famous Wat idea. Few stick around long enough to understand the long-term...

In this Fully-Connected episode, Daniel and Chris explore DALL-E 2, the amazing new model from Open AI that generates incredibly detailed novel images from text captions for a wide range of concepts expressible in natural language. Along the way, they acknowledge that some folks in the larger AI community are suggesting that sophisticated models may be approaching sentience, but together they pour...

This week Adam is taking the show off the beaten path to speak with Adam Miller, the founder and CEO of Revel Bikes. Yes that's right, this episode features a founder of a bike brand, not a tech brand. Adam Miller's journey to create Revel Bikes is paved with many ups and many downs, a failed partnership, super scrappy weeks and months traveling the world to find the best manufacturing partners, t...

Anthony Hobday has 37 ways to spice up your designs, James Bennett has opinions on open source and PyPi security, Alicia Sykes compiled some awesome security/privacy options, ContextKeeper layouts out the real price of context switching, and Nick Nisi tells us all about jqq. Bam! Bam! Bam!

This week we're talking with Daniel Thompson about Tauri and their journey to their recent 1.0 release. Tauri is often compared to Electron - it's a toolkit that lets you build software for all major desktop operating systems using web technologies. It was built for the security-focused, privacy-respecting, and environmentally-conscious software engineering community. The core libraries are writte...

Deno team member Luca Casonato joins Jerod & Feross to tell us about Fresh – a next generation web framework, built for speed, reliability, and simplicity.

This week Adam is joined by Robert Ross founder and CEO of FireHydrant — the glue layer between your tech stack and your teams to mitigate and resolve incidents at scale. Robert shares his journey to become a software engineer, his time at DigitalOcean, this idea of incident management as a platform and how he shifted his focus from creating courses on incident management to recognizing the value...