Biotech 2050
Biotech 2050 Podcast
Biotech2050 Podcast is a think tank chronicling the disruptions changing the biotech industry over the next 50 years.
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Episodes
110. Novel cell and gene therapies, Mark Gergen, CEO, Poseida Therapeutics, Inc. 13.07.2022 29:40
Mr. Gergen was appointed Chief Executive Officer of Poseida in February 2022. He joined Poseida in February 2018, initially serving as Chief Business Officer and Chief Financial Officer before being named President and Chief Business Officer in July 2020. He has been a member of the Company’s board of directors since 2018. Mr. Gergen was previously the Senior Vice President and Chief Operating Off...
109. Gene therapy CDMO, Tim Miller, CEO, Erandi De Silva, SVP of Prod. Dev., Forge Biologics 29.06.2022 21:50
Timothy J. Miller, Ph. D. CEO, President and Co-Founder Timothy Miller is CEO, President and Co-Founder of Forge Biologics, Inc., a VC-backed gene therapy development engine focused on accelerating access to potentially life-saving AAV gene therapies. Prior to founding Forge, Dr. Miller co-founded Abeona Therapeutics, a rare disease gene and cell therapy company. He served as Abeona’s CEO and Pres...
108. Vibe Bio launches to transform drug development, Alok Tayi Ph.D. and Susanna Harris Ph.D. 22.06.2022 19:40
Our guest this week is one of our hosts, Alok Tayi, and he has some exciting news. The official launch of his new company, Vibe Biotechnology, building a global community of patients, scientists, and partners around a shared mission to cure rare diseases. Vibe Bio's novel approach seeks to scale the development of treatments sustainably and provides patient communities unprecedented ownership over...
107. Fighting infectious diseases with biologics, Paul Garofolo, Co-founder & CEO, Locus Biosciences 15.06.2022 30:18
Paul is the CEO & Co-founder of Locus Biosciences. With a career that spans manufacturing, research & development, information technology and corporate transformations, Paul brings a broad range of experience and capability to deliver on the Locus vision. Prior to Locus, Paul was Chief Technology Officer at Patheon Pharmaceuticals and also held the role of Global Head of Operations for Patheon’s P...
106. Next-Gen CRISPR applications, Trevor Martin, Co-founder & CEO, Mammoth Biosciences 08.06.2022 25:03
Dr. Trevor Martin founded Mammoth Biosciences with the mission to enable the next generation of CRISPR-based synthetic biology products across therapeutics and diagnostics, including a novel class of affordable, effective, and rapid CRISPR-enabled molecular diagnostics that allow individuals worldwide to better understand their health and a novel family of CRISPR Cas14 proteins that can enable in...
105. Gene therapy in hearing loss, Laurence Reid, PhD, CEO, Decibel Therapeutics 01.06.2022 37:48
Laurence joined Decibel in January 2020. He previously served as an entrepreneur in residence at Third Rock Ventures, where he focused on novel drug discovery and development opportunities. Before that, Laurence was CEO of Warp Drive Bio, a small molecule company focused on novel oncology and antibiotic drug discovery based on natural products, until its merger with Revolution Medicines in 2018. P...
104. Embracing nerve repair, Karen Zaderej, CEO, Chairman, and President, Axogen 25.05.2022 26:18
Ms. Zaderej has served as Axogen’s President, Chief Executive Officer, and a member of our Board of Directors since September 2011 and the Chairman of our Board of Directors since May 2018. Since May 2010, she has served as the Chief Executive Officer of Axogen’s wholly owned subsidiary, Axogen Corporation, and a member of the Board of Directors of Axogen Corporation. Ms. Zaderej joined Axogen Cor...
103. Patient-driven thrombosis innovations, John Glasspool, CEO, Anthos Therapeutics 18.05.2022 24:11
John Glasspool is CEO and member of the Board of Directors of Anthos Therapeutics. Mr. Glasspool is also a member of the Board of Directors of Dalcor Corporation. He was formerly the Executive Vice President, Head of Corporate Strategy and Customer Operations at Baxalta Incorporated (NYSE: BXLT), formerly Baxter BioScience (NYSE: BAX). Prior to joining Baxter in August 2012, Mr. Glasspool was Head...
102. Vanquishing Parkinson's Disease, Jim Sullivan, PhD, Co-founder & CEO, Vanqua Bio 11.05.2022 22:29
Dr. Sullivan is co-founder and CEO of Vanqua. In addition, he has been a Venture Partner with Orbimed since January 2019. Previously, he was the Vice President of Research at Abbvie where he was responsible for the company’s research efforts in a variety of therapeutic/disease areas including oncology, immunology, neurology, hepatitis C and cystic fibrosis. Jim has advanced more than 100 compounds...
101. Revolutionizing genetic medicine, Paula Soteropoulos, Chairman of the Board, Ensoma 04.05.2022 29:33
Paula Soteropoulos brings to Ensoma more than 30 years of experience in the biopharma industry in areas of drug development, manufacturing, business development, global commercialization with P&L accountability, company building and organizational development. Her leadership throughout her career spans a broad range of therapeutic areas, including rare disease, cardiovascular and metabolism, infec...
100. Disruptive forces in biotech, Jake Becraft, Lex Rovner, Josh Mandel-Brehm, & Nabiha Saklayen 27.04.2022 1:05:40
Jake Becraft is co-founder and CEO of Strand Therapeutics, an emerging biotechnology company at the forefront of mRNA therapeutics. With colleagues at MIT’s Synthetic Biology Center, he led the development of the world’s first synthetic biology programming language for mRNA. Jake has been featured in Fierce Biotech, Bloomberg, and the Boston Business Journal, among others, for his vision and missi...
99. Precision medicine for sepsis, Tim Sweeney, Co-Founder and CEO, Inflammatix, Inc. 20.04.2022 19:54
Tim Sweeney, MD, PhD, is co-founder and CEO of Inflammatix. Tim has extensive experience in medical practice (general & trauma surgery), bench research, and bioinformatics / machine learning. While training at Stanford he helped invent the core technology on which Inflammatix is based, is named on over a dozen patents related to medical diagnostics, and has published >100 manuscripts & abstracts....
98. Brain health disorders, Al Robichaud, Ph.D., CSO, Sage Therapeutics 13.04.2022 18:51
Al leads teams in early-stage discovery up through non-clinical development, identifying new drug candidates for advancement into clinical research. Al joined Sage as CSO in 2011, with more than 20 years of drug discovery experience focused primarily in the neuroscience arena. Most recently, he was Vice President of Chemistry and Pharmacokinetic Sciences at Lundbeck USA, where he was responsible f...
97. Patient driven treatments in rare diseases, Stuart Peltz, Founder & CEO, PTC Therapeutics 06.04.2022 28:04
Dr. Stuart Peltz founded PTC Therapeutics in 1998 and has served as Chief Executive Officer and a member of the Board of Directors since the company’s inception. Under his leadership, PTC has grown from a research organization to a publicly traded, global commercial organization with multiple approved products and a foundation of strong technology platforms that continues to drive a robust discove...
96. Obesity & rare disease, Patrick Kleyn, SVP and Head of Translational R&D,Rhythm Pharmaceuticals 30.03.2022 20:15
Patrick Kleyn joined Rhythm in 2018 with over 25 years’ experience in human genetics and genomics, and he was named as head of TRAD in 2021. Prior to joining Rhythm, Patrick has held leadership roles in academia, biotech and large pharmaceutical companies, as his work has focused on the application of genomic technologies for drug and biomarker discovery and development. He began his career at Mil...
95. Gene writing, Dr. Jake Rubens, Co-Founder & CIO, Hari Pujar, COO, Tessera Therapeutics 23.03.2022 25:59
Jacob(Jake)Rubens, Co-Founder, Chief Innovation Officer Jake is Co-Founder and Chief Innovation Officer of Tessera Therapeutics, as well as a Principal at Flagship Pioneering. Jake joined Flagship Pioneering in 2015 and works as part of a venture-creation team, founding and growing companies based on new biotechnology. At Flagship, Jake launched Kaleido Biosciences and co-founded Sana Biotechnolog...
94. Cell therapy in a war on cancer, Kleanthis Xanthopoulos, Co-Founder & CEO, Shoreline Biosciences 16.03.2022 25:14
Kleanthis is a serial biotechnology entrepreneur with over two decades of experience in the biotechnology and pharmaceutical research industries as an executive, company founder, chief executive officer, investor and board member. Dr. Xanthopoulos has founded five companies, introduced three life science companies to NASDAQ and financed and brokered numerous creative strategic alliance and partner...
93. Human-centric data and AI for improved drug development, David Berry, Founder & CEO, Valo Health 09.03.2022 33:11
David Berry is the Founder and CEO of Valo and since 2005, has served as General Partner at Flagship Pioneering, having founded over 25 companies including Indigo Agriculture, Seres Therapeutics (NASDAQ: MCRB), Eleven Biotherapeutics (NASDAQ: EBIO), T2 Biosystems (NASDAQ: TTOO), Evelo Biosciences (NASDAQ: EVLO), Axcella Health (NASDAQ: AXLA), and Joule Unlimited. David played an instrumental role...
92. Software driven biology for small molecule mRNA drugs, Yochi Slonim, Co-founder & CEO, Anima 02.03.2022 40:01
A serial entrepreneur in software and biotech, Yochi Slonim has built multiple companies as a founder and CEO through all phases of growth all the way to IPOs and large M&A exits. As a Co-founder and CEO of Anima Biotech, he is driving the company's vision and strategy, fundraising, and partnering. Prior to Anima, Yochi was a co-founder of Mercury Interactive. As CTO and VP R&D from the company's...
91. tRNA therapies, Lovisa Afzelius, Founding CEO, Theonie Anastassiadis, Co-founder & CIO, Alltrna 23.02.2022 28:44
Lovisa Afzelius is an origination partner at Flagship Pioneering and the former SVP of Strategy & Operations at Flagship-founded Cogen Immune Medicines, now known as Repertoire Immune Medicines. A computational scientist by training, she has two decades of leadership experience and a passion for data-driven drug discovery, from early inception to clinical development across multiple therapeutic ar...
90. From pharma to founding a biotech, James Mackay, Founder, President & CEO, Aristea Therapeutics 16.02.2022 24:41
James Mackay, PhD, Founder, President and Chief Executive Officer, has over 25 years of development and commercialization expertise in the pharmaceutical industry, including 6 drug product approvals across multiple therapeutic areas. Prior to founding Aristea, he was President and Chief Executive Officer of Ardea Biosciences, Inc., following the company’s acquisition by AstraZeneca in 2012. James...
89. Regenerative medicine pioneer, Laura Niklason, Founder, President, & CEO, Humacyte, Inc. 09.02.2022 33:38
A physician-scientist, her groundbreaking work in vascular and lung engineering has made Dr. Niklason a world leader in regenerative medicine. She is a member of the National Academies of Engineering and Medicine. Dr. Niklason is the founder of Humacyte and has served as President and Chief Executive Officer since November 2020 and as a member of the Humacyte Board since 2004. Dr. Niklason holds a...
88. Biologics in autoimmune and kidney disease, Marshall Fordyce, CEO and Founder, Vera Therapeutics 02.02.2022 20:14
Dr. Fordyce brings more than 15 years’ experience leading teams in drug discovery, development, clinical translation, and commercialization of new treatments. Before founding Vera, Fordyce was the founder and CEO of gene-editing company Trucode Gene Repair, Inc., having previously served as an entrepreneur in residence at Kleiner Perkins Caufield and Byers. Earlier in his career, Fordyce served as...
87. Patient-centric Duchenne gene therapy, Joel Schneider, COO, Solid Biosciences 26.01.2022 34:46
Dr. Schneider is the Chief Operating Officer for Solid Biosciences, responsible for overseeing corporate and technical operations, quality, patient advocacy, communications, corporate strategy, and human resources. As Solid’s first employee in 2014, Dr. Schneider was instrumental in discovering and executing proof-of-concept studies for SGT-001, as well as building the company’s unique disease-foc...
86. Resilient to the core, Trish Hurter, CEO, Jess Ballinger, President & COO, Lyndra Therapeutics 19.01.2022 31:00
Patricia (Trish) Hurter, Dr. Patricia Hurter is CEO of Lyndra Therapeutics. Prior to Lyndra, Dr. Hurter was Senior Vice President of Pharmaceutical and Preclinical Sciences at Vertex Pharmaceuticals, Inc. She also served as Interim Head of Global Regulatory Affairs from 2013-2014 and oversaw several label expansions for Kalydeco® and the submission of the new drug application for Orkambi®. She pla...
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