Big Picture Science

It will be the shot heard ‘round the world, once it comes. But exactly when can we expect a COVID vaccine? We discuss timelines, how it would work, who’s involved, and the role of human challenge trials.  Also, although he doesn’t consider himself brave, we do. Meet a Seattle volunteer enrolled in the first coronavirus vaccine trial. And, while we mount an elaborate defense against a formidable fo...

To fight a pandemic, you need to first understand where a virus comes from. That quest takes disease ecologist Jon Epstein to gloomy caverns where bats hang out. There he checks up on hundreds of the animals as his team from the EcoHealth Alliance trace the origins of disease-causing viruses. But their important work is facing its own threat; the Trump administration recently terminated funding to...

A new theory about life’s origins updates Darwin’s warm little pond. Scientists say they’ve created the building blocks of biology in steaming hot springs. Meanwhile, we visit a NASA lab where scientists simulate deep-sea vent chemistry to produce the type of environment that might spawn life. Which site is best suited for producing biology from chemistry? Find out how the conditions of the early...

Nature abhors a vacuum, but conspiracy theorists love one. While we wait for scientists to nail down the how and why of the coronavirus, opportunists have jumped into the void, peddling DIY testing kits and fake COVID cures like colloidal silver. They’ve even cooked up full-blown conspiracy theories about a lab-grown virus. Find out why this crisis has dished up more than the usual share of misinf...

Treating the Virus It’s not like waiting for Godot, because he never arrived. A coronavirus vaccine will come. But it is still months away. Meanwhile, scientists are adding other weapons to our growing arsenal against this virus. The development of antibody tests, antibody cures, and antivirals offer hope that we can soon have the tools to battle those who’ve been sickened by the COVID-19 virus wh...

Reason for hope is just one thing that ecologist Carl Safina can offer. He understands why many of us turn to nature to find solace during this stressful time. Safina studies the challenges facing the ultimate survival of many species, but also gives a portrait of animals from their point of view. He describes how diverse animals such as sperm whales, bear cubs, macaws, and chickens deal with unce...

What do a zombie attack and a viral pandemic have in common? They are both frightening, mindless, and relentless in their assault. And both require preparedness.  That’s why the author of “World War Z” – a story about a battle against zombies – lectures at West Point.  Max Brooks has also recorded a public service announcement with his celebrated father, Mel Brooks, touting the importance of socia...

Humans aren’t the only animals stressed-out by social distancing. Narwhals send out echolocation clicks to locate their buddies and ease their loneliness. And a plant about to be chomped by a caterpillar knows that the world can be a scary place.  In this episode, from dogs to narwhals to plants, we put aside human-centric stories to find out how other living creatures map their world, deal with s...

“Climate change at warp speed” is the way one scientist described the coronavirus outbreak.   In a show recorded before a live audience at the Seattle AAAS meeting, and co-presented with the BBC World Service, we discuss out how politics and psychology lead people to tune out inconvenient scientific findings even when the stakes are high – as well as what we can do about it. Guests: Roland Pease –...

Astronauts are made of the “right stuff,” but what about their spacesuits?  NASA’s pressurized and helmeted onesies are remarkable, but they need updating if we’re to boldly go into deep space.  Suiting up on Mars requires more manual flexibility, for example. Find out what innovative materials might be used to reboot the suit. Meanwhile, strange new materials are in the pipeline for use on terra...

Contagion aside, coronavirus is a powerful little virus. It has prompted a global experiment in behavior modification: elbow bumps instead of handshakes, hand sanitizer and mask shortages, a gyrating stock market.  Pragmatism motivates our behavior toward the spread of this virus, but so do fear and panic. In 1918, amplified fear made the Spanish Flu pandemic more deadly.  Can we identify when we’...

They were pioneers in their fields, yet their names are scarcely known – because they didn’t have a Y chromosome. We examine the accomplishments of two women who pioneered code breaking and astronomy during the early years of the twentieth century and did so in the face of social opprobrium and a frequently hostile work environment. Henrietta Leavitt measured the brightnesses of thousands of stars...

The benefits of artificial intelligence are manifest and manifold, but can we recognize the drawbacks … and avoid them in time?  In this episode, recorded before a live audience at the Seattle meeting of the American Association for the Advancement of Science, we discuss who is making the ethical decisions about how we use this powerful technology, and a proposal to create a Hippocratic Oath for A...

Have you adapted to the changing climate? Rising waters, more destructive wildfires, record-breaking heatwaves. Scientists have long predicted these events, but reporting on climate change has moved from prediction to description. There’s no time for dwelling on “we should haves.” Communities and organizations are being forced to adapt. Find out what that means, the role of the new “resilience off...

It’s one of the most bizarre biological experiments ever. In the 18th century, a scientist fitted a pair of tailor-made briefs on a male frog to determine the animal’s contribution to reproduction. The process of gestation was a mystery and scientists had some odd-ball theories.  Today, a 5th grader can tell you how babies are made, but we still don’t know exactly what life is. In our quest to und...

Climate change isn’t happening. Vaccines make you sick. When it comes to threats to public or environmental health, a surprisingly large fraction of the population still denies the consensus of scientific evidence. But it’s not the first time – many people long resisted the evidentiary link between HIV and AIDS and smoking with lung cancer. There’s a sense that science denialism is on the rise. It...

Your daily mucus output is most impressive. Teaspoons or measuring cups can’t capture its entire volume. Find out how much your body churns out and why you can’t live without the viscous stuff. But slime in general is remarkable. Whether coating the bellies of slithery creatures, sleeking the surface of aquatic plants, or dripping from your nose, its protective qualities make it one of the great i...

What’s the difference between a bird call and the sound of a pile driver? Not much, when you’re close to the loudest bird ever. Find out when it pays to be noisy and when noise can worsen your health. Just about everyone eventually suffers some hearing loss, but that’s not merely aging. It’s an ailment we inflict on ourselves. Hear how a team in New York City has put sensors throughout the city to...

Get ready for compassionate computers that feel your pain, share your joy, and generally get where you’re coming from. Computers that can tell by your voice whether you’re pumped up or feeling down, or sense changes in heart rate, skin, or muscle tension to determine your mood. Empathetic electronics that you can relate to. But wait a minute – we don’t always relate to other humans. Our behavior c...

You are your brain. But what happens when your brain changes for the worse – either by physical injury or experience? Are you still responsible for your actions? We hear how the case of a New York man charged with murder was one of the first to introduce neuroscience as evidence in court. Plus, how technology hooks us – a young man so addicted to video games, he lacked social skills, or even a des...

Do we still need doctors? There are umpteen alternative sources of medical advice, including endless and heartfelt health tips from people without medical degrees. Frankly, self-diagnosis with a health app is easier and cheaper than a trip to a clinic.  Since we’re urged to be our own health advocate and seek second opinions, why not ask Alexa or consult with a celebrity about what ails us? Find o...

The stress of the holidays can make you want to hide under the covers with a warm cup of cocoa. From gift buying to family gatherings, the holidays can feel like being inside a pressure cooker. But don’t despair! Science can help make the holidays a little brighter, from some gift-giving tips from our animal friends to embracing pessimism before a challenging social event to stopping that annoying...

Why create more landfill? Perhaps you should resist the urge to toss those old sneakers, the broken ceiling fan, or last year’s smart phone. Instead, repurpose them! Global junk entrepreneurs are leading the way in turning trash to treasure, while right-to-repair advocates fight for legislation that would give you a decent shot at fixing your own electronic devices.  And, if you toss food scraps d...

(repeat) We all may retreat to our protective shells, but evolution has perfected the calcite variety to give some critters permanent defense against predators. So why did squids and octopuses lose their shells? Find out what these cephalopods gained by giving up the shell game. Plus why Chesapeake Bay oyster shells are shells of their former selves. What explains the absence of the dinner-plate s...

(repeat) Fir tree needles embedded in carpet are a holiday headache. Why not decorate a genetically-modified, needle-retaining tree instead? It’s just another way that science is relevant to the holidays. We have more. How about science experiments on fruitcake? There’s a competition that includes launching it with a pneumatic device, running a heavy electric current though it, or blasting it with...