Authentic Biochemistry

Dr Guerra investigates T and B cell mediated autoimmune induction in this critical podcast lecture before the full analysis of these destructive human diseases are authentically examined in the peer-reviewed biomedical literature.

As it turns out, autoimmune bacterial  epitope mimicry can play a crucial role in autoimmune primary biliary cholangitis and may correlate to major human disorders such as lupus . Prof. Guerra examines a series of papers from the primary literature to focus attenuation on T cell sub-population differentiating dynamics production.related to Plasma cell IgG 

T Lymphocyte communication with antigen presenting innate immune cells coupled with B cell activation may be regulated by a glycoprotein that links to discrete glycosylation patterns on membrane polypeptide domains

The epigenetic control over gene expression via transcriptional and post-transcriptional molecular interactions through time including interfering RNA and covalent modification of chromatin results in enivonmental, nutritional and age-related phenotypes . In this episode of Authentic Biochemistry, Dr. Guerra starts investigating  the molecular mechanisms employed.

Professor Guerra begins an arc of lectures on the molecular events that describe the covalent modification and temporal variation of gene expression collectively called epigenetics.

Prof Guerra gives a brief examination of Leptin -associated cancers. 15 October 2019

Dr Guerra discusses the intricate roles of Leptin and its receptor in various human diseases. 10 October. 2019

Dr Guerra of Authentic Biochemistry provides his  third discussion of adipokine-mediated control over obesity and associated disease from animal models to clinical disease. 02 October 2019.

Dr Dan Guerra pursues how Leptin and POMC regulate neuroendocrine and neuro-appetitive behaviours that link obesity and associated metabolic and life-style disease with the dysregulation of energy homeostasis

Dr. Guerra of Authentic Biochemistry and the VerEvMed YouTube channel provides critical in-depth neuro-anatomical and HPA axial complicity in Leptin Signaling from the Adipose to the stress- and basal regulation of human physiological responsiveness. 22 September 2019 

In this Authentic Biochemistry Podcast Episode Prof. Guerra describes the specific metabolism of very long chain polyunsaturated fatty acids from essential dietary precursors of both the Omega 6 and Omega 3 series and associates these pathways with a recent 2019 publication that provides evidence for Omega 3 fatty acid inhibition of adipose stem cell associated IL17a  proinflammatory  cy...

Authentic Biochemistry's Dr Daniel Guerra implements his keen understanding of lipid metabolism to uncover the network of cellular, subcellular and pathway domains  regulating fatty acid oxygenation and both glycerol-and sphingosine- lipid signaling that function to mediate cell fate and the inflammatory response in relation to dietary omega three fatty acid.   04 Sept 2019.

Dr. Guerra of Authentic Biochemistry discusses a current published paper that shows how DHA and EPA derived from dietary alpha linolenic acid (18:3 cis  d 9,12,15) correlates with a decrease in the production of the pro-inflammatory cytokine, IL17-A in a model system composed of obese adipose stem cell populations.

This is volume VI of the Tregs lecture narrative in which Dr. Guerra provides an introduction to a  Diaeventontological  process for navigating the labyrinth of T cell biochemistry. Published 17 August 2019.  Authentic Biochemistry Podcast. 

Treg and Th cells are under transcriptional modulation via cytokine mediated control of a Nfil3 protein that serves to block FOXp3 expression. DR Guerra verifies the evidence in the data from a recent paper: Experimental & Molecular Medicine volume 51, Article number: 80 (2019) that demonstrated Inhibition of the TGF-β signaling pathway led to increased Nfil3 expression which blocked Foxp3 tra...

Prof. Guerra provides a narrative focusing on  evolutionary perspectives and  the resultant lymphocyte differentiating foundations for the adaptive immune response as a means to apprehend the event-ontological diverse transcriptional mediation ultimately landing on the Treg FOXp3 promoter . Part IV 

In this Authentic Biochemistry episode Dr Guerra unfolds the complex transcription factor and membrane & nuclear- receptor repertoire associated cytokine and chemokine axis activating and maintaining Treg cell differentiation to mediate the Th pro- inflammatory response

Dr Dan Guerra presents "T regulatory Cells in Human Biology and Disease. An update on transcriptional control". Vol. I. This first segment introduces the elaborate nature of innate and acquired lymphoid cells and the transcription factors that drive lineage differentiation. 

This is a brief introduction to what will be a multi-segmented sequence of podcasts on the complexity of T cell mediated immunity and its native regulation via Treg  activation. 

In this podcast, Authentic Biochemistry's own Dr. Dan Guerra ties the actuated Moebius strip of anti-apoptosis rendered neuronal differentiation amidst  a tempest of ceramide synthetic possibility.

Dr Guerra of Authentic Biochemistry navigates through the protease inhibitor literature and starts a journey into hepatitis C virus (HCV)-mediated HCC induction and some of the pharmacotherapies  impacting this axis.

Dr. Guerra focuses on emerging  signaling and immunoepigenetic  variations around the theme of protease inhibitor mediation of various stages and forms of solid organ and metastatic tumorigenesis in this June 29,2019 installment of Authentic Biochemistry.

Dr Dan Guerra reveals that serine protease inhibitors (Serpins) are endogenous proteins that block protease-mediated metastasis and cancer associated fibroblast activation in some tumor microenvironments but not all. The myriad 'labyrinth' interactions among cytokines , proteases, protease inhibitors and the dysregulation of the T-lymphocytic immune response obtains a confounding pharmacotherapeut...

Dr. Guerra of Authentic Biochemistry provides a primer on polypeptide  proteases and their mode of action as well as their control via processing and  inhibition in clinical medicine

Serine proteinases and their peptide inhibitors, the SERPINS, have a role to play in liver pathology and disease  potentiation leading to subcellular protein aggregation, enhanced  inflammation and ultimate hepatocellular carcinoma. Dr. Guerra of Authentic Biochemistry introduces this new plank in the knowledge platform being constructed to apprehend either the necessary or sufficient co...