Astral Codex Ten Podcast

140 million obese Americans x $15,000/year for obesity drugs = . . . uh oh, that can't be right. https://astralcodexten.substack.com/p/semaglutidonomics   Semaglutide started off as a diabetes medication. Pharma company Novo Nordisk developed it in the early 2010s, and the FDA approved it under the brand names Ozempic® (for the injectable) and Rybelsus® (for the pill).   I think "Ozempic" sounds l...

I wrote an article on whether wine is fake. It's not here, it's at asteriskmag.com , the new rationalist / effective altruist magazine. Congratulations to my friend Clara for making it happen. Stories include: Modeling The End Of Monkeypox: I'm especially excited about this one. The top forecaster (of 7,000) in the 2021 Good Judgment competition explains his predictions for monkeypox. If you've ev...

Plus FTX charges, scandal markets - and oh yeah, wasn't there some kind of midterm recently? https://astralcodexten.substack.com/p/mantic-monday-twitter-chaos-edition Twitter! This is all going to be so, so obsolete by the time I finish writing it and hit the "send post" button. But here goes: 395 traders on this, so one of Manifold's biggest markets, probably representative. The small print defin...

https://astralcodexten.substack.com/p/the-psychopharmacology-of-the-ftx Must not blog about FTX . . . must not blog about . . . ah, $#@% it         Tyler Cowen linked Milky Eggs' excellent overview of the FTX crash. I'm unqualified to comment on any of the financial or regulatory aspects. But it turns out there's a psychopharmacology angle, which I am qualified to talk about, so let's go. I wrote...

https://astralcodexten.substack.com/p/contra-resident-contrarian-on-unfalsifiable I. Contra Resident Contrarian . . . Resident Contrarian writes On Unfalsifiable Internal States , where he defends his skepticism of jhana and other widely-claimed hard-to-falsify internal states. It's long, but I'll quote a part that seemed especially important to me: I don't really want to do the part of this artic...

https://astralcodexten.substack.com/p/can-people-be-honestly-wrong-about A tangent of the jhana discussion : I asserted that people can't be wrong about their own experience. That is, if someone says they don't feel hungry, maybe they're telling the truth, and they don't feel hungry. Or maybe they're lying: saying they don't feel hungry even though they know they really do (eg they're fasting, and...

https://astralcodexten.substack.com/p/highlights-from-the-comments-on-brain [original post here ] On What Kind Of Thing Brain Waves Are: Loweren writes : In my undergrad biology program we visited a brain research lab near Moscow. The brain scientist gave us a brief intro to Fourier transforms, which made me understand how beautiful they are - something that 2 years of undergrad math classes didn'...

https://astralcodexten.substack.com/p/highlights-from-the-comments-on-my [Original post here ] I know I don't usually publish on Saturdays, but I wanted to get this out before people filled in their mail-in ballots. So: Is Prop 31 Another Attack On Vaping?   Maximum Limelihood Estimator is concerned that Prop 31 (against flavored tobacco products) is meant to target vaping: The flavored tobacco ba...

https://astralcodexten.substack.com/p/acx-grants-project-updates         Thanks to everyone who got ACX Grants ( see original grants here ) and sent me a one-year update. Below are short summaries of the updates everyone sent. If for some reason you want one of the full updates, which are longer and more technical, let me know and I'll see if I have permission to send them to you. I've also includ...

https://astralcodexten.substack.com/p/my-california-ballot-2022 Previously: 2018 , 2020 General Philosophy Of Voting   This is California, so the Democrats always win. When I vote, I mean to send a signal somewhere in between "you are the candidate I really prefer for this office" and "I will vote for the Democrat if I approve of her and want her to have a mandate; otherwise I will vote for the Re...

https://astralcodexten.substack.com/p/moderation-is-different-from-censorship This is a point I keep seeing people miss in the debate about social media. Moderation is the normal business activity of ensuring that your customers like using your product. If a customer doesn't want to receive harassing messages, or to be exposed to disinformation, then a business can provide them the service of a ha...

https://astralcodexten.substack.com/p/highlights-from-the-comments-on-jhanas "I think it's the first time half the commenters accused the other half of lying" I. Is Jhana Real?   This was a fun one. I think it's the first time half the commenters accused the other half of lying. Okay, "half" is an exaggeration. But by my count we had 21 people who claimed to have experienced jhanas ( 1 , 2 , 3 , 4...

https://astralcodexten.substack.com/p/book-review-malleus-maleficarum I. To The Republic, For Witches Stand Did you know you can just buy the Malleus Maleficarum ? You can go into a bookstore and say "I would like the legendary manual of witch-hunters everywhere, the one that's a plot device in dozens of tired fantasy novels". They will sell it to you and you can read it. I recommend the Montague...

https://astralcodexten.substack.com/p/nick-cammarata-on-jhana Buddhists say that if you meditate enough, you can learn to enter a state of extreme bliss called jhana. (there are many different jhana states - there's a discussion of the distinctions here - but I'm lumping them together for simplicity. For attempted explanations of why jhana should exist, see here and here .) Jhana is different from...

https://astralcodexten.substack.com/p/highlights-from-the-comments-on-supplement [Original post here: How Trustworthy Are Supplements? ] 1: AvalancheGenesis writes : I think the bigger issue is that the industry as a whole sort of exists as solutions-in-search-of-problems...deficiencies really aren't that common, or even meaningfully health-affecting unless dire. (Fairly-arbitrary worldwide differ...

Answers to the questions I get most often at meetup Q&As https://astralcodexten.substack.com/p/from-the-mailbag DEAR SCOTT: When are you going to publish Unsong? — Erik from Uruk Dear Erik, Aaargh. I have an offer from a publisher to publish it if I run it by their editor who will ask me to edit lots of things, and I've been so stressed about this that I've spent a year putting it off. I could sel...

https://astralcodexten.substack.com/p/book-review-rhythms-of-the-brain Brain waves have always felt like a mystery. You learn some psychology, some neuroscience, a bit of neuroanatomy. And then totally separate from all of this, you know that there are things called "brain waves" that get measured with an EEG. Why should the brain have waves? Are they involved in thinking or feeling or something?...

https://astralcodexten.substack.com/p/another-bay-area-house-party [Previously: Every Bay Area House Party ] Blaise Pascal said all human evil comes from inability to sit alone in a room. Your better nature - your rational soul - tells you that nothing good has ever come from attending large social events. But against that better nature stands the Devil, wielding a stick marked "FOMO". If you don'...

What do Sam Altman, Matt Bruenig, and the Sacramento Kings have in common? -- Are the polls wrong? -- CFTC vs. Everybody https://astralcodexten.substack.com/p/mantic-monday-101722 Midterm Examination   Polls this year look bad for Senate Republicans. Pollsters' simulations give them a 22% chance ( Economist ), 34% chance ( 538 ), or 37% chance ( RaceToTheWH ) of taking power. Even Mitch McConnell...

https://astralcodexten.substack.com/p/highlights-from-the-comments-on-the-3b1 Original post: Why Is The Central Valley So Bad?   1: Several Valley residents commented with their perspectives. Some were pretty grim. For example, 21st Century Salonniere (writes The 21st Century Salon ) writes: It is horrible. It's been horrible since at least 1996 when I got trapped here by my spouse's job. We were...

https://astralcodexten.substack.com/p/links-for-october-397 [Remember, I haven't independently verified each link. On average, commenters will end up spotting evidence that around two or three of the links in each links post are wrong or misleading. I correct these as I see them, and will highlight important corrections later, but I can't guarantee I will have caught them all by the time you read...

https://astralcodexten.substack.com/p/highlights-from-the-comments-on-columbus [Original post: A Columbian Exchange ] 1: The most popular comments were those objecting to my paragraph about holidays replacing older holidays: All of our best holidays have begun as anti-holidays to neutralize older rites. Jesus was born in the spring; they moved Christmas to December to neutralize the pagan Solstice...

https://astralcodexten.substack.com/p/a-columbian-exchange Adraste: Happy Indigenous People's Day! Beroe: Happy Columbus Day! Adraste: …okay, surely we can both sketch out the form of the argument we're about to have. Genocide, political correctness, moral progress, trying to destroy cherished American traditions, etc, etc, would you like to just pretend we hit all of the usual beats, rather than...

Due to an oversight by the ancient Greeks, there is no Muse of blogging. Denied the ability to begin with a proper Invocation To The Muse, I will compensate with some relatively boring introductions. The name of this blog is Slate Star Codex. It is almost an anagram of my own name, Scott S Alexander. It is unfortunately missing an "n", because anagramming is hard. I have placed an extra "n" in the...

Also Austin, Seattle, Tokyo, Rome, Mumbai, etc. We have two Southern California meetups this weekend: Los Angeles at 6:30 PM Saturday October 8 at 11841 Wagner St, Culver City. San Diego at 3 PM on Sunday, October 9, at Bird Park, these coordinates . See here for more details. I think I'll be able to make it to both; if for some reason that changes I'll try to update you by Open Thread beforehand....