American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

In this episode author, Melissa Nelson of Baylor University Medical Center, discusses the recently published manuscript titled "Th2 Cytokine Signaling through IL-4Rα Increases Eotaxin-3 Secretion and Tension in Human Esophageal Smooth Muscle."   New and Noteworthy: Nelson et al. have found that Th2 cytokines increase eotaxin-3 secretion and tension in esophageal smooth muscle (ESM) cells via IL-4R...

In this podcast, authors Maria A. Ilomäki and Lauri Polari (both at Åbo Akademi University) discuss their recently published research titled “Defining a timeline of colon pathologies after keratin 8 loss: Rapid crypt elongation and diarrhea are followed by epithelial erosion and cell exfoliation.”   New and Noteworthy: Understanding the order in which physiological and molecular events occur helps...

In this episode authors Katherine L. Prowse,, and Elyanne M. Ratcliffe of McMaster University, discuss their recently published article titled “Effects of in utero exposure to fluoxetine on the gastrointestinal tract of rat offspring.”   NEW & NOTEWORTHY There is increasing recognition of the relevance of in utero and early postnatal exposures in the developmental programming of the gastrointe...

Diego Alvarez de la Rosa of the University of La Laguna discusses the recently published manuscript titled “Decaying kidney function during cirrhosis correlates with remodeling of distal colon aldosterone target gene expression.”   NEW & NOTEWORTHY Liver cirrhosis progression significantly alters ion transporter subunit expression in the rat distal colon, a change that correlated well with dec...

In this podcast lead author Dr. Stella Liong of RMIT University, discusses the recently published manuscript titled “Influenza A virus infection during pregnancy causes immunological changes in gut-associated lymphoid tissues of offspring mice.”   NEW & NOTEWORTHY Influenza A virus (IAV) infection during pregnancy is associated with changes in gut-associated lymphoid tissue (GALT) in the offsp...

First author, Dr. Kalidas Ramamoorthy of the University of California, Irvine discusses the recently published paper titled “miR-122-5p is involved in posttranscriptional regulation of the mitochondrial thiamin pyrophosphate transporter (SLC25A19) in pancreatic acinar cells.”   NEW & NOTEWORTHY This study shows that the expression and function of mitochondrial TPP transporter (MTPPT) are subje...

In this podcast  Steven Hutchens and Dr. Somshuvra Mukhopadhyay of the University of Texas at Austin discuss the recently published research titled "Hepatic and intestinal manganese excretion are both required to regulate brain manganese during elevated manganese exposure."    NEW & NOTEWORTHY This article shows that, in contrast with expectations from prior studies and physiological condition...

In this episode, Dr. Jihane N. Benhammou of UCLA discusses the recently published article titled "Lipophilic statins inhibit YAP coactivator transcriptional activity in HCC cells through Rho-mediated modulation of actin cytoskeleton."   NEW & NOTEWORTHY Statins are widely used for the treatment of cardiovascular diseases. Recently, their use has been associated with a decrease in the incidence...

In this podcast coauthors Francisco Pascual, and Samuel Camilli of Morsani College of Medicine, University of South Florida discuss the recently published Perspectives titled "Mind-body connection: metabolite 4-ethylphenyl linked to anxiety behavior and oligodendrocyte modification in autism spectrum disorder."   Article Citation: Mind-body connection: metabolite 4-ethylphenyl linked to anxiety be...

In this podcast Prof. Theo A.T.G. van Kempen of North Carolina State University and Dr. Gavin M. Boerboom of Trouw Nutrition discuss their recently published perspectives paper titled "Is the intestinal mucous layer a natural deep eutectic solvent-based digestion matrix?"   Article Citation: Is the intestinal mucous layer a natural deep eutectic solvent-based digestion matrix? Theo A.T.G. van Kemp...

In this podcast first author Dr. Jessica A. Breznik of McMaster University, discusses the recently published manuscript titled "Diet-induced obesity alters intestinal monocyte-derived and tissue-resident macrophages and increases intestinal permeability in female mice independent of tumor necrosis factor."    NEW & NOTEWORTHY We found that diet-induced obesity in female mice has tissue- and ti...

In this micro podcast Dr. Gene G. Lamanilao The University of Tennessee Health Science Center, College of Medicine gives the listeners an overview the recently published manuscript titled "Key hepatoprotective roles of mitochondria in liver regeneration."    Treatment of advanced liver disease using surgical modalities is possible due to the liver’s innate ability to regenerate following resection...

Take a listen to our latest podcast with coauthor Dr. Yoshi Sei as he discusses the recently published manuscript " Tissue- and cell-specific properties of enterochromaffin cells affect the fate of tumorigenesis toward nonendocrine adenocarcinoma of the small intestine " with Editor in Chief Professor Mark Frey. Small intestinal neuroendocrine tumors are of putative enterochromaffin (EC) cell orig...

Take a listen to our latest podcast where the magnificent Dr. Karen Edelblum, chair of the GI and Liver Section discusses what's happening at our first ever American Physiology Summit, April 20-23rd in Long Beach California. Registration Deadline for American Physiology Summit is March 31, 2023 Click here for more info on American Physiology Gastrointestinal and Liver Physiology

Get to know author Dr. Rodger Liddle (Duke University) in this latest podcast as he goes over his recently published manuscript " Initiation and severity of experimental pancreatitis are modified by phosphate " with Editor in Chief Professor Mark Frey.    New and Noteworthy-Impaired ATP synthesis disrupts acinar cell homeostasis and is an early step in pancreatitis. We report that reduced phosphat...

In this podcast authors Prof D. Mark Pritchard and Dr. Carrie Duckworth of the University of Liverpool, discuss their recently published manuscript “ Nfkb2 deficiency and its impact on plasma cells and immunoglobulin expression in murine small intestinal mucosa ” with Editor-in-Chief Prof. Mark Frey. Novel transcriptomic analysis of murine proximal intestinal mucosa revealed an unexpected B cell s...

In our latest podcast senior author Dr. Rhonda Souza discusses her latest published research “ A Human Barrett's Esophagus Organoid System Reveals Epithelial-Mesenchymal Plasticity Induced by Acid and Bile Salts ” with Editor-in-Chief Prof. Mark Frey. Using Barrett's esophagus (BE) biopsies, the authors established organoids recapitulating key BE features. During early stages of organoid developme...

In this podcast, coauthors Dr. Huajun Han, and Prof. Robert S. Chapkin of Texas A&M University, discuss their recently published research " Loss of aryl hydrocarbon receptor suppresses the response of colonic epithelial cells to IL22 signaling by upregulating SOCS3 " with Editor-in-Chief Prof. Mark Frey. Data from their preclinical orthogonal models indicate that AhR signaling modulates the respon...

In today’s episode Dr. Stephen Keely from the Royal College of Surgeons in Ireland and Prof Kim Barrett of the University of California, Davis talk about their recent review article “ Mechanisms of Secretory Diarrhea ” with Prof Mark Frey. They discuss why it is we need to talk more about diarrheal diseases, lift the lid on the complex cellular and molecular mechanisms involved, and look to where...

In a rapidly evolving era of single cell technologies, the authors of " Stiffness is associated with hepatic stellate cell heterogeneity during liver fibrosis " explain the mechanism of an amplification loop during liver fibrosis. By deciphering how stiffness macro and microscopic heterogeneity promote differential gene expression in hepatic stellate cell sub-populations, the authors find a novel...

Get to know senior author Dr. Liara M. Gonzalez of North Carolina State University as she discusses the recently published paper entitled "HOPX+ injury-resistant intestinal stem cells drive epithelial recovery after severe intestinal ischemia" with EIC Prof. Mark Frey.  This paper supports that rISCs are resistant to ischemic injury and likely an important source of cellular renewal following near...

Looking for a new pharmacological approach to treat gastrointestinal motility disorders? In this podcast authors Dr. Daniel Poole and Dr. Simona Carbone of Monash University discuss their recent paper, where they investigated the therapeutic potential of a positive allosteric modulator to enhance endogenous delta-opioid receptor signaling in the gut. Take a listen today!  Jesse J. DiCello, Simona...

Three investigators at Children's Hospital Los Angeles, Nandini Girish, Dr. Cambrian Liu, and Dr. Brent Polk, talk about their recent work to visualize the fates and functions of epithelial stem cells in models of inflammatory bowel disease with Editor-in-Chief Professor Mark Frey. The investigators discuss their diverse backgrounds, reveal how they started the work, and begin a spirited debate on...

Many times we read a manuscript but don’t really get to know the amazing author behind the great science.  Behind those black typewritten letters that spell a scientists name lies a person that is usually creative, intelligent, quirky, and fun.  This is certainly the case with the author of “Use of human tissue stem cell-derived organoid cultures to model enterohepatic circulation”, Dr. Sarah Blut...

Welcome to AJP- Gastrointestinal Liver’s Physiology’s Podcast series, Got Guts? Our first episode is a  joint effort with Dr. Pradeep Dudeja, Chair of the GI and Liver Section and Dr. Karen Edelblum, Chair of GI and Liver Program Committee with host Editor-In-Chief, Professor Mark Frey. In this podcast we will be talking about all things Experimental Biology 2022. For more information on Experimen...