AI + a16z

In this episode of AI + a16z, General Partner Anjney Midha shares his perspective on the recent collection of Nobel Prizes awarded to AI researchers in both Physics and Chemistry. He talks through how early work on neural networks in the 1980s spurred continuous advancement in the field — even through the "AI winter" — which resulted in today's extremely useful AI technologies. Here's a sample of...

In this episode of AI + a16z, General Partner Anjney Midha explains the forces that lead to GPU shortages and price spikes, and how the firm mitigates these concerns for portfolio companies by supplying them with the GPUs they need through a program called Oxygen. The TL;DR version of the problem is that competition for GPU access favors large incumbents who can afford to outbid startups and commi...

In this episode of AI + a16z, Bowen Peng and Jeffrey Quesnelle of Nous Research join a16z General Partner Anjney Midha to discuss their mission to keep open source AI research alive and activate the community of independent builders. The focus is on a recent project called DisTrO, which demonstrates it's possible to train AI models across the public internet much faster than previously thought pos...

In this episode of AI + a16z, Ambience cofounder and chief scientist Nikhil Buduma joins Derrick Harris to discuss the nuances of using AI models to build vertical applications (including in his space, health care), and why industry acumen is at least as important as technical expertise. Nikhil also shares his experience of having a first-row seat to key advances in AI — including the transformer...

In this episode of AI + a16z, a16z General Partner Jennifer Li joins MotherDuck Cofounder and CEO Jordan Tigani to discuss DuckDB's spiking popularity as the era of big data wanes, as well as the applicability of SQL-based systems for AI workloads and the prospect of text-to-SQL for analyzing data. Here's an excerpt of Jordan discussing an early win when it comes to applying generative AI to data...

In this episode of the AI + a16z podcast, Black Forest Labs founders Robin Rombach, Andreas Blattmann, and Patrick Esser sit down with a16z general partner Anjney Midha to discuss their journey from PhD researchers to Stability AI, and now to launching their own company building state-of-the-art image and video models. They also delve into the topic of openness in AI, explaining the benefits of re...

In this episode, a16z General Partner Vijay Pande walks us through the past two decades of applying software engineering to the life sciences — from the Folding@Home project that he launched, through AlphaFold and more. He also discusses the major opportunities for AI to transform medicine and health care, as well as some pitfalls that founders in that space need to watch out for. Here's an excerp...

In this episode of the AI + a16z podcast, a16z General Partner Anjney Midha speaks with PromptFoo founder and CEO Ian Webster about the importance of red-teaming for AI safety and security, and how bringing those capabilities to more organizations will lead to safer, more predictable generative AI applications. They also delve into lessons they learned about this during their time together as earl...

In this episode of the AI + a16z podcast, Command Zero cofounder and CTO Dean de Beer joins a16z's Joel de la Garza and Derrick Harris to discuss the benefits of training large language models on security data, as well as the myriad factors product teams need to consider when building on LLMs.  Here's an excerpt of Dean discussing the challenges and concerns around scaling up LLMs: "Scaling out in...

In this episode of the AI + a16z podcast, Anyscale cofounder and CEO Robert Nishihara joins a16z's Jennifer Li and Derrick Harris to discuss the challenges of training and running AI models at scale; how a focus on video models — and the huge amount of data involved — will change generative AI models and infrastructure; and the unique experience of launching a company out of the UC-Berkeley Sky Co...

In this archive episode from 2015, a16z's Sonal Chokshi, Frank Chen, and Steven Sinofsky discuss DeepMind's breakthrough AlphaGo system, which mastered the ancient Chinese game Go and introduced the public to reinforcement learning. Check out everything a16z is doing with artificial intelligence here , including articles, projects, and more podcasts.   Hosted by Simplecast, an AdsWizz company...

In this episode of the AI + a16z podcast, Luma Chief Scientist Jiaming Song joins a16z General Partner Anjney MIdha to discuss Jiaming's esteemed career in video models, culminating thus far in Luma's recently released Dream Machine 3D model that shows abilities to reason about the world across a variety of aspects. Jiaming covers the history of image and video models,  shares his vision for the f...

In this episode, design engineer Alasdair Monk joins a16z's Yoko Li and Derrick Harris to discuss how generative AI is changing how developers — and the those building for developers — interact with the tools of their trade. Alasdair’s journey includes stints at dev-centric companies such as Heroku/Salesforce, and he's presently designing the user experience for Poolside, an AI programming startup...

In this episode, Inngest cofounder and CEO Tony Holdstock-Brown joins a16z partner Yoko Li, as well as Derrick Harris, to discuss the reality and complexity of running AI agents and other multistep AI workflows in production. Tony also why developer tools for generative AI — and their founders — might look very similar to previous generations of these products, and where there are opportunities fo...

In this episode, Ideogram CEO Mohammad Norouzi joins a16z General Partner Jennifer Li, as well as Derrick Harris, to share his story of growing up in Iran, helping build influential text-to-image models at Google, and ultimately cofounding and running Ideogram. He also breaks down the differences between transformer models and diffusion models, as well as the transition from researcher to startup...

For this holiday weekend (in the United States) episode, we've stitched together two archived episodes from the a16z Podcast , both featuring General Partner Anjney Midha. In the first half, from December, he speaks with Mistral cofounder and CEO Arthur Mensch about the importance of open foundation models, as well as Mistral's approach to building them. In the second half (at 34:40), from Februar...

a16z partners Guido Appenzeller and Matt Bornstein join Derrick Harris to discuss the state of the generative AI market, about 18 months after it really kicked into high gear with the release of ChatGPT — everything from the emergence of powerful open source LLMs to the excitement around AI-generated music. If there's one major lesson to learn, it's that although we've made some very impressive te...

In this bonus episode, recorded live at our San Francisco office, security-startup founders Dean De Beer (Command Zero), Kevin Tian (Doppel), and Travis McPeak (Resourcely) share their thoughts on generative AI, as well as their experiences building with LLMs and dealing with LLM-based threats. Here's a sample of what Dean had to say about the myriad considerations when choosing, and operating, a...

In this episode of the AI + a16z podcast, a16z General Partner Zane Lackey and a16z Partner Joel de la Garza sit down with Derrick Harris to discuss how generative AI — LLMs, in particular — and foundation models could effect profound change in cybersecurity. After years of AI-washing by security vendors, they explain why the hype is legitimate this time as AI provides  a real opportunity to help...

Socket Founder and CEO Feross Aboukhadijeh joins a16z's Joel de la Garza and Derrick Harris to discuss the open-source software supply chain. Feross and Joel share their thoughts and insights on topics ranging from the recent XZutils attack to how large language models can help overcome understaffed security teams and overwhelmed developers.  Despite some increasingly sophisticated attacks making...

In this episode, though, we’re traveling back in time to distant — in AI years, at least — past of 2020. Because amid all the news over the past 18 or so months, it’s easy to forget that generative AI — and LLMs, in particular — have been around for a while. OpenAI released its GPT-2 paper in late 2018, which excited the AI research community, and in 2020 made GPT-3 (as well as other capabilities)...

Pinecone Founder and CEO Edo Liberty joins a16z's Satish Talluri and Derrick Harris to discuss the promises, challenges, and opportunities for vector databases and retrieval augmented generation (RAG). He also shares insights and highlights from a decades-long career in machine learning, which includes stints running research teams at both Yahoo and Amazon Web Services. Because he's been at this a...

a16z General Partner Anjney Midha joins the podcast to discuss what's happening with hardware for artificial intelligence. Nvidia might have cornered the market on training workloads for now, but he believes there's a big opportunity at the inference layer — especially for wearable or similar devices that can become a natural part of our everyday interactions.  Here's one small passage that speaks...

Naveen Rao, vice president of generative AI at Databricks, joins a16z's Matt Bornstein and Derrick Harris to discuss enterprise usage of LLMs and generative AI. Naveen is particularly knowledgeable about the space, having spent years building AI chips first at Qualcomm and then as the founder of AI chip startup Nervana Systems back in 2014. Intel acquired Nervana in 2016. After a stint at Intel, R...

There are few terms in the world of AI — if any — that invoke more of a reaction than a simple four-letter word: Open. Whether it’s industry debates over business models and the actual definition of open, or the US government actively discussing how to regulate open models, seemingly everyone has an opinion on what it means for AI models to be open. The good, the bad, and the ugly. But to be fair,...