CHRONO:MEDICINE

Your host Frieder introduces the topic of light and its influence on human physiology. Properties of light, such as the visible wavelength spectrum of light as well as ultra-violett (UV) and infrared light, are described. Differences between natural daylight and electric artificial light are pointed out. Time-of-day dependency of the influence of light on physiology is highlighted with a special f...

M.Sc. Saar Ezagouri (Gad Asher's Lab, Weizmann Institute of Science, Rehovot, Israel) talks about his study on daily variance in exercise capacity, in which he showed that mice as well as humans have a higher capacity to perform moderate intensity endurance exercise in their respective late activity phase of the day, corresponding to evening hours in humans. We discuss the role of the molecula...

Dr. Nicholas Saner (Baker Heart and Diabetes Institute, Melbourne, Australia) talks about his study on how exercise can reduce the negative metabolic impact of sleep restriction. We discuss the overall role of mitochondria in skeletal muscle for metabolic health and zoom into his findings on mitochondrial respiration and sarcoplasmic protein synthesis after sleep restriction in combination with ex...

Dr. Jonathan Cedernaes (Northwestern University and Uppsala University) talks about the acute effects of sleep loss on skeletal muscle, adipose tissue and glucose metabolism. Sleep loss is associated with weight gain and loss of muscle mass in humans and insufficient sleep is considered a risk factor to develop obesity and metabolic diseases. We discuss Dr. Cedernaes' recent findings on the mo...

Prof. Karyn Esser from the University of Florida introduces the circadian clock present in skeletal muscle. We discuss how muscle clocks... work when comparing mice that are active at night to humans that are active during the day; influence metabolism and exercise performance; can be altered by environmental factors such as light, temperature, food intake and muscle contractions at different time...

In this episode, Frieder introduces the general idea of the 247MUSCLE podcast and himself. Papers that I refer to: Muscle cramps induce muscle hypertrophy: "Electrically induced muscle cramps induce hypertrophy of calf muscles in healthy adults" http://www.ismni.org/jmni/pdf/60/14BEHRINGER.pdf Electric muscle stimulation to treat muscle cramps: "Neuromuscular Electrical Stimulation...