Authentic Biochemistry

Dr Guerra discusses the Glucocorticoid-induced tumour necrosis factor receptor-related protein (GITR) and its role in stabilizing T Regulatory cell populations relative to T memory cells and T effector Cells in healthy and End-Stage Renal Disease patients of differing chronological age. This plank is laid down to form the final structural foundations that allow us to examine dialectically, the rol...

Dr Guerra builds the foundation for transcription factor and epigenetic regulation of Treg cell differentiation in counterbalance to ILC's and T effector lymphocyte populations. Published 01 September 2020.

Dr. Daniel Guerra  recombines the discussions of pharmacotherapeutic inhibition of prenylation in T cell activation and the failure of the NF-Kappa B pathway in estrogen receptor associated  breast cancer and the lymphoproliferative lymphomas and leukemias with aging and neurodegeneration. PUblished 24 August 2020. Please join our Patreon and contribute to Authentic Biochemistry today!

Dr Guerra discusses the induction of transcription factor SREBP in activated T lymphocytes  and the regulation of cellular translocation from the ER to the Golgi to the nucleus for the induction of prenyl and acyl lipogenesis, Published 18 August 2020 by Dr Daniel J. Guerra.  Review of: Front. Pharmacol., 17 March 2020.   https://doi.org/10.3389/fphar.2020.00265

In this segment I discuss the phenomenon of DNA and genomic instability and the DNA repair systems implemented  as mechanisms to drive cellular longevity . 06 August 2020 .

Programmed Cell Death is a classical cell fate that occurs during embryonic development, tissue repair and both leucocyte and lymphocyte turnover. Various subforms of apoptosis ( classical, necroptosis and ferroptosis) are also involved during infection, genotoxicity, oncogenesis and aging. Published By Dr Guerra 05 August 2020. Subscribe to the podcast! Contribute on Patreon! 

Dr Guerra discusses the cancer marker gene mKI67 and its turnover linked to predisposition to euchromatin formation and the progression toward a senescent phenotype. Published 04 August 2020.

The mevalonic acid biosynthetic pathway maintains canonical cell activation triggers that link intermediary metabolism to T lymphocyte differentiation. 02 August 2020

The master regulator of protein translation, mTORC, is itself regulated by the stress-induced AMPK pathway. Rapamycin and semi-selective drugs regulating  AMPK may reduce glioblastoma progression and this observation helps to advance a theory for healthy longevity that requires a reduction in anabolism. By Dr Daniel J. Guerra. Published 01 August 2020

In this lecture I gather some of the notable molecular components of age-related decline and the contrarion opposition imposed by cell proliferation. Published 30 July 2020. DJGPhD. 

Dr Dan Guerra examines nutritional restriction and exercise in combination with anti-diabetic drugs to impact the aging process. Published 27 July 2020.

Dr Guerra explains chain initiation, propagation and  termination during  lipid oxidation and the REDOX reactions of the electron transport chain  as a lead in to enzymatic oxidations and the plasticity of immune linked senescence. 26 July 2020.

Dr Guerra lays out the reduction of molecular oxygen to water and the accumulation of intermediate free radical oxygen species that are reduced via enzymatic activity and anti=oxidants. Aging is related to the auto-oxidation of nucleic acids, protein and significantly, membrane unsaturated molecular species of lipids. 24 July 2020

Dr Guerra explains how  mutations in the glycolytic enzyme, pyruvate kinase,  may lead to histone phosphorylation and the florid production of pro-oncogenic events. 24 July 2020.

Dr. Guerra delivers lecture 2 on human aging with a walk on the other side of cell fate:-pathobiochemical immortalization during oncogenesis. Published 21 July 2020

Today I start this robust examination of human aging from the fundamentals of life span and the molecular events that mediate the rate of senescence. This is Part One. Also please consider contributing to Authentic Biochemistry by becoming a patron on Patreon. I need your support!  https://podbay.fm/podcast/1454408625

The synthesis of protease-mediated hyper inflammation in pre-morbid respiratory distress pathobiochemical states linked to coronavirus transmission . How COPD and ARDS in association with cardiovascular disease, diabetes and lung dysfunction pre-dispose to viral infection and illness. Published 11 July 2020.

Airway passage disease has been well characterized in  cystic fibrosis and this research which involves both clinical and animal model systems can inform general respiratory distress syndrome and viral pneumonia as that ascribed to the coronavirus 19. Published 10 July 2020

Dr Guerra presents his existential view on the purposive avoidance  in science to admit the significance of belief in the knowledge paradigm. 09 July 2020.

Dr Guerra recaps protease mechanisms and zymogen activation ultimately linking serpin mediation of neutrophil elastase during coronavirus infection. Published 08 July 2020

Dr Guerra presents how a protease inhibitor protects a serine protease that is linked to ovarian cancer progression plus how protease inhibitor polymerization overloads the Endoplasmic Reticulum Associated Degradation pathway and Unfolded Protein Response to induce autophagy-linked Hepatocellular Carcinoma. Finally,  a mechanistic step-wise summary of the serine protease catalytic triad &nbsp...

Far from becoming monomeric and unimodal in effect, the anti-trypsin protease inhibitor functions to modulate the transcriptome and proteome of induced pro-inflammatory responses in both systemic and  tumor microenvironments.  Dr Dan Guerra 30 June 2020

Dr Guerra targets his lecture on protease inhibitors as positive acute phase proteins serving a modality of repression against proteolytic degradation processes as induced by the pro-inflammatory cytokine mediated hyper-immune response. Published 29 June 2020.

In this  session Dr Guerra discusses the physiological and pathophysiological roles of serine protease inhibitors (SERPINS). For example,  the physiological role of plasminogen activator inhibitor 1 (PAI-1) involves control over fibrinolysis  which is an essential  hemostatic mechanism for regulating the dissolution of fibrin clots associated with airway passage remodeling &nbs...

In this Lecture I define and then implement  a dialectical approach to biomedical scientific research methods that involves event ontologies relative to a non-paradoxical understanding of cancer pathobiochemistry. Published 19 June 2020 by Dr Daniel Guerra