Authentic Biochemistry

ImmunoEpigenetics 100B. Fine. The apodictic recombination-dependent TCR and Ig receptor system is mediated by epigentic modifications.DJGPhD.29.7.23. Authentic Biochemistry 30.07.2023 29:30 ↓

References Mol Cancer. 2023 Apr 10;22(1):69 Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12410-12415 Semin Immunol. 2010 Dec; 22(6): 311–312

ImmunoEpigenetics100A. The Tcell repose and ILC differentiation via E vs ID chromatin remodeling antagonism. DJGPhD.28.7.23. Authentic Biochemistry Podcast. 28.07.2023 30:00 ↓

Reference Front Immunol.2022; 13: 890056. previous IE lectures 1-3.

ImmunoEpigenetics 99. Tregs can foster a massive tumor microenvironment inhibition of T-eff cell populations via neo-antigen activation from dying tumor cells leading to cancer progression. DJGPhD 27.07.2023 29:30 ↓

Reference Cancers (Basel). 2021. Apr; 13(8): 1850.

ImmunoEpigenetics 98. TCR mediated protection from neonate infection is naturally suppressed. BCG VAX may be a treatment against Type 1 Diabetes by increasing Treg mediated autoimmune suppression. 26.07.2023 29:59 ↓

References NPJ Vaccines. 2018; 3: 23. Immunol Cell Biol. 2022 Aug; 100(7): 562–579

ImmunoEpigenetics97.Bcell maturation involves a multilevel epigenetic mark-up of differentiating pathways to subsequently respond to T cell activation upon 2nd signal stimulation. DJGPhD.24.7.23 24.07.2023 29:56 ↓

References Cellular & Molecular Immunology. 2022. volume 19, pages 1215–1234. Front. Cell Dev. Biol. 2022. 07 January Sec. Epigenomics and Epigenetics # 805195

ImmunoEpigenetics96. APC-agMHCII and Bcell:Tcell synapse interactions yield subsequent plasma cell antibody production under the H3K4me3 epigenetic alteration of chromatin accessibility.DJGPhD.23.7.23 23.07.2023 29:18 ↓

References J Immunol. 2014 Aug 15; 193(4): 1531–1537 Immunology lecture notes-Guerra

Mountain Pass Adventure I. The "five best" and an excursion into asymmetry. Dr. Daniel J. Guerra. 22.7.23. Authentic Biochemistry Podcast. 23.07.2023 29:29 ↓

Inspirations A hot summer day and what passes as a ponder on the asymmetric.

ImmunoEpigenetics 95. Does H3K4 trimethylation play a quantitative or qualitative role in nascent activation of neonatal naive T cells toward a specific polarity of gene expression?DJGPhD.20.7.23 20.07.2023 29:59 ↓

Reference Immunol Cell Biol. 2022 Aug; 100(7):562–579.

ImmunoEpigenetics. 94. Neonate TCR stimulation and subsequent signaling circumventing TCR specificity differ from adult activation and cytokine expression. DJGPhD. 19.7.23. Authentic Biochemistry 20.07.2023 28:31 ↓

Reference Immunol Cell Biol. 2022 Aug; 100(7):562–579.

ImmunoEpigenetics 93. tTREG's not only control Th differentiation and proliferation but in an HLA-antigen mediated specificity thus differentiating CD4+ vs CD8+ inflammation as directed by 6mA. 19.07.2023 30:00 ↓

References Signal Transduction and Targeted Therapy 2021.volume 6, Article number: 412. Nature Immunology. 2022. volume 23, pages 1208–1221.

ImmunoEpigenetics 92. thymic Treg populations alter Th1 differentiation. Antigen presenting DC's coordinate TCR with associated membrane proteins to support activation via PM lipid sequence.DJGPhD. 17.07.2023 30:00 ↓

References J Biol Chem. 2021 Jul;297(1):100900 Immunol Rev. 2014 May; 259(1):88–102.

ImmunoEpigenetics91. WTAP conditional deletion via LoxPCre controlled by FoxP3 obtains a Treg phenotype incapable of supressing murine spontaneous colitis. DJGPhD. 15.7.23. Authentic Biochemistry. 15.07.2023 29:59 ↓

Reference Nature Immunology 2022. volume 23, pages 1208–1221.

ImmunoEpigenetics90. Tcell receptor organization activation and adaptor protein ligand molecular signaling is regulated down stream by 6methyl mRNA speciation.DJGPhD.7July2023.Authentic Biochemistry 11.07.2023 29:16 ↓

References Nature Immunology 2022. volume 23, pages 1208–1221 Signal Transduction and Targeted Therapy 2021. volume 6, Article number: 412.

Enzyme Kinetics sensu strictu. The Michaelis Menten equations and precison of the kcat. DJGPhD.9July23b. Authentic Biochemistry Podcast. 10.07.2023 29:47 ↓

References Guerra lectures archives

Primer on enzyme kinetics in clinical biochemical research. DR. Daniel J. Guerra. 09July2023. Authentic Biochemistry Podcast Productions 09.07.2023 30:00 ↓

Dr Guerra lecture notes

PhotosynthesisV. Photorespiration and synthesis of this holiday arc: fait accompli. DJGPhD.08July23b. Authentic BiochemistryPodcast. 09.07.2023 29:59 ↓

References Guerra's plant biochemistry lectures

Photosynthesis 4. Chlorophyll and carotene biosynthesis and some further detail on the mechanism of the Mn-H20 splitting complex of p680 PSII and diatomic molecular oxygen (O2) evolution.DJGPhD. 7July 08.07.2023 30:00 ↓

References Plant Biochemistry lectures archives :Guerra Phys. Chem. Chem. Phys., 2020,22, 7912-7934 Nature Plants 2017. volume 3, Article number:17041

Photosynthesis 3. Dr Daniel J Guerra. 07July2023 Authentic Biochemistry Podcast productions 06.07.2023 29:53 ↓

Guerra: Plant biochemistry Lectures

Unique Lecture Post holidayIV. Photosynthesis 2. DJGPhD.05July23b Authentic Biochemistry Podcast production. 05.07.2023 30:00 ↓

References Plant Biochemistry Lectures -Guerra

Unique Lecture Series Post holiday. III Higher plant photosynthesis 1. DJGPhD. 05July2023. Authentic Biochemistry Podcast. 05.07.2023 30:00 ↓

References Guerra. Plant Biochemistry lectures

Unique Lecture Series Holiday Time 4th of July2023.Non-arbitrary C-C bond formation chemistry: Aldol and Claisen condensation with Stork enamine synthesis (i.e. Michael reactions) 04.07.2023 29:54 ↓

Reference Organic chemistry : reaction mechanism lectures

Unique Lecture Series . Holiday Time. 4th of July 2023! Hydrocarbons. 01.07.2023 30:00 ↓

Very basic lecture material

ImmunoEpigenetics 89. Final synthesis of statin drug mediated alteration of metabolism in T lymphocytes. DJGPhD.6.30.23. Authentic Biochemistry Podcast. 30.06.2023 29:56 ↓

References Cancer Discov. 2022 Mar 1; 12(3): 856–871. Previous 5 lectures in Authentic Biochemistry and refs. contained therein https://youtu.be/dyy0p90GO2w

ImmunoEpigenetics 88. Statin treatment of early progenitor T cell acute lymphoblastic leukemia could pose biochemical impositions on healthy lymphocyte populations. DJGPhD.29.6.23.Authentic Biochem. 30.06.2023 29:56 ↓

References Oncotarget 2021.12.(13) Cancers (Basel). 2020 Aug 1;12(8):213 Cancer Discov. 2022 Mar 1; 12(3): 856–871

ImmunoEpigenetics87. Competitive inhibition of HMGCoA-R may enhance apoptosis while blocking cholesterologenesis and GGPP covalent modification of signaling kinases to thwart ETP-All in cell culture. 28.06.2023 29:58 ↓

References JBC.2002. Volume 277, ISSUE 2, P1128-1138. Cancer Discov. 2022 Mar 1; 12(3): 856–871. Guerra lectures-lipid metabolic regulation Guerra lectures-pharmacodynamics and kinetics