The Human Upgrade: Biohacking for Longevity & Performance

This week's stories:   *Mud Playgrounds Double Kids' Bacterial Diversity and Spike Immune Genes 30%  Finland swapped rubber playground surfaces for natural soil and mud across eight kindergartens — and after just one month, kids in dirt had twice the bacterial species diversity on their skin and a 30% increase in expression of ten immune-related genes. Dave breaks down why your immune sy...

Your cells are starving for oxygen, and it's silently driving inflammation, fatigue, brain fog, and accelerated aging. This episode reveals how pairing Exercise with Oxygen Therapy (EWOT) and red light therapy supercharges your mitochondria, reverses pseudo-hypoxia, and unlocks a level of human performance most people never experience.    -Save up to $500 (throug...

If you're a woman in your 30s, 40s, or 50s feeling like your body is betraying you, this episode reveals the hormonal, gut, and environmental triggers behind perimenopause that most doctors never address, and exactly what you can do about it.    -Watch this episode on YouTube for the full video experience:  https://www.youtube.com/@DaveAspreyBPR   Host Dave Asprey sit...

When you hit your 40s, you start catching colds more easily, wounds take longer to heal, and you feel rundown even after a full night's sleep. Your doctor will tell you "it's just aging." They're wrong. It's actually your immune cells suffocating on toxic waste because their power plants—your mitochondria—are breaking down. In this video, I explain the exact biological mechanism behind "immune agi...

Frog venom burns your skin, makes you purge, and might be the most powerful healing tool you have never tried. In this episode, Host Dave Asprey sits down with Kambo researcher and practitioner Caitlin Thompson to break down how intentional suffering through this ancient Amazonian medicine is producing dramatic results for people with autoimmune conditions, chronic illness, Lyme disease,...

Your brain is aging faster than it should, and most of the decline is self-inflicted. Neuroscientist Dr. Tommy Wood reveals the exact mechanisms driving cognitive decay, and the biohacking strategies backed by hard science that can stop it, reverse it, and future-proof your brain at any age.  -Watch this episode on YouTube:  https://www.youtube.com/@DaveAspreyBPR   Host Dave Asprey...

You are not eating because you are hungry. You are eating because you have been trained to, and the food industry designed it that way. This episode dismantles everything you thought you knew about hunger, weight loss, and metabolism, and gives you a science-backed framework to finally stop fighting your own biology.    -Watch this episode on YouTube:  https://www.youtube.com/@DaveA...

I lost 100 pounds, dropped to 4.8% body fat, and my lab tests say I'm biologically in my 30s... at 50 years old. Here's everything I got wrong about weight loss for years, and what actually worked. After 18 months of low-calorie dieting and 700+ hours in the gym with zero fat loss, I discovered the truth about saturated fat, intermittent fasting, and why putting butter in my coffee every morning c...

This week's stories:  ***Virologist Self-Injects Oncolytic Virus Therapy, Achieves 4-Year Remission in Triple-Negative Breast Cancer***  A researcher facing terminal triple-negative breast cancer (28% 5-year survival rate) engineered her own measles and vesicular stomatitis viruses and self-administered seven doses directly into her tumor outside formal clinical infrastructure....

Your body already makes the most powerful wound-healing molecule on the planet, and now you can use it at home. This episode breaks down hypochlorous acid (HOCl), the compound your white blood cells produce naturally, and why it outperforms Neosporin, hydrogen peroxide, and synthetic antibiotics for everything from cuts and burns to eczema, rosacea, and chronic wounds.    -Watch this epi...

The government is finally catching up to what biohackers have known for decades, and the man helping lead that charge just sat down with Host Dave Asprey to talk longevity science, aging biomarkers, dietary overhaul, AI in medicine, and what a real science-first health agenda actually looks like.    Watch this episode on YouTube for the full video experience:  https://www.youtube.co...

My favorite creatine (discount code DAVETUBE): https://www.qualialife.com/ASPREYRECOMMENDS Creatine isn’t just for bodybuilders. It’s one of the most overlooked, science-backed nootropics for brain optimization, neuroplasticity, mitochondrial energy, and total human performance. This episode reveals why creatine is a non-negotiable supplement for anyone serious about biohacking, longevity, and cog...

This week's stories:  *Bartonella Hides in Cat Scratches — and It Might Be Why You Feel Like Garbage  A stealth bacterial infection transmitted by everyday cat scratches and flea dirt has been quietly linked to chronic fatigue, brain fog, and neurological symptoms for decades. Dave breaks down how Bartonella slips past standard testing, why it's almost never on a conventio...

Most women are suffering for years from anxiety, gut problems, low libido, and brain fog because no one is treating the real cause: their hormones. This episode is a masterclass in women's hormone optimization, covering everything from vaginal delivery of bioidentical hormones to why low estrogen destroys your gut, your sex drive, your mitochondria, and your marriage.    Watch this episo...

I spent over $2 million hacking my own biology to reverse my age, but one of the most powerful discoveries didn’t come from a pharmaceutical lab. It came from NASA. Try Danger Coffee: https://dangercoffee.com/dave (Discount Code DAVETUBE) Try Energy Bits: https://energybits.com/discount/dave Astronauts face the harshest environment known to science: space radiation. To keep them alive, NASA had to...

Your home could be quietly stealing your IQ, disrupting your hormones, destroying your mitochondria, and triggering chronic disease, and most people never connect the dots. This episode gives you the full picture on toxic mold, and exactly what to do about it  Learn More About The Superstratum Products Dave Uses At: https://superstratumlabs.com/products/dave  Host Dav...

Autism is reversible, and the science to prove it already exists. This episode delivers a master class on the biological roots of autism, what actually triggers it, and the protocols that have helped real families recover their children, including one mom who sold everything she owned to make it happen.  Host Dave Asprey sits down with Tracy Slepcevic, bestselling author of War...

Most people buying "clean" supplements are unknowingly loading their bodies with heavy metals, rancid fish oil, and glyphosate, even inside products labeled organic and healthy. This episode breaks down exactly what the supplement industry refuses to tell you and gives you the tools to stop poisoning yourself every morning.  -Watch this episode on YouTube for the full video experien...

Try TrueDark (with my discount): https://truedark.com/discount/DAVETUBE I have spent 20 years and over $2 million testing my biology, and the biggest lesson I've learned is that sleep is a neurological system, not just a chemical one. Most people fail to get deep rest because they are stuck in Beta brainwaves—a state of hypervigilance fueled by stress and blue light. You can take all the melatonin...

Your brain is hardware, and if the hardware is broken, no supplement stack, nootropic, or biohacking protocol in the world will get you to full capacity. This episode goes inside the most advanced stem cell and brain optimization clinic on the planet, where Host Dave Asprey undergoes a cutting-edge neurocognitive protocol that combines focused ultrasound, transcranial magnetic stimulation, and mes...

What if the real reason you feel stuck, anxious, or unfulfilled has nothing to do with your biohacking stack and everything to do with which half of your brain you're actually using? In this episode, Host Dave Asprey sits down with Harvard professor and bestselling author Arthur Brooks to reveal the neuroscience of meaning, consciousness, and why your left brain's obsession with optimiza...

Your gut microbiome controls your brain chemistry, your stress response, your sleep, your metabolism, and your ability to lose weight, and most people have no idea how broken theirs actually is.  Watch this episode on YouTube for the full video experience:  https://www.youtube.com/@DaveAspreyBPR   Get 20% off your next purchase of OMNi-BiOTiC with code ‘Dave20’ at:&nb...

Try TrueDark (with my discount): https://truedark.com/discount/DAVETUBE I transformed my vision from 20/80 to 20/15 by stopping the "management of decline" and starting the "restoration of tissue". The retina is a metabolically hungry tissue that undergoes a nightly repair program, but modern habits like screen use and late-night blue light exposure suppress the melatonin and mitochondrial energy...

This week's stories:  *SNL Roasts the MAHA Movement  Saturday Night Live took direct aim at RFK-adjacent anti-vaccine culture in a sketch that lampoons raw milk, bull semen, energy healers, and "natural immunity" rhetoric — and it landed with a mainstream audience. Dave breaks down what it means when fringe health narratives become national punchlines, and why being a biohacker means sta...

Your thyroid controls your energy, your metabolism, your testosterone, your mood, and your ability to think clearly. Most doctors are testing it wrong and treating it wrong, and this episode tells you exactly what to do instead.  -Watch this episode on YouTube for the full video experience:  https://www.youtube.com/@DaveAspreyBPR   Host Dave Asprey sits down with McCall McPherson, a...