Physionic

In this episode, we'll be beginning our look at senescent cells, how and why they occur, as well as the main drivers of senescence in aging and disease. Video Podcast: https://youtu.be/NcBpJv5WIhY Scientific Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748990/pdf/JCB_201708092.pdf MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN -...

In this episode, we'll be discussing how different types of saturated and unsaturated fats impact mitochondria in our muscle cells. Video Podcast: https://youtu.be/2T9I1FmlFyE Study: https://link.springer.com/content/pdf/10.1007/s00125-005-1895-z.pdf MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Conte...

In this episode, I discuss some of the valid and non-valid (by my estimation) critiques of the recent ketogenic diet study I covered on the YouTube channel. I also discuss the nutrition style that I follow, specifically. Video Podcast: https://youtu.be/eE2QpdRSeFY Keto Damages the Heart Video: https://youtu.be/CAkjoT28yZw Keto Damages the Heart Podcast: https://youtu.be/lpns8gfR3H8 MY BOOKS, COURS...

In this episode, I discuss a study looking at how a protein (Emilin) and a molecule (TGF-beta) create a scenario in which high blood pressure occurs in animals *and* in the same effect is seen in humans with high blood pressure. Study: https://pubmed.ncbi.nlm.nih.gov/30354220/ Video Podcast: https://youtu.be/88GqvZ2XjrM MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine'...

In this episode, I discuss how, and potential reasons why, cancer cells feed off sugar/glucose. Scientific Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783224/ Video Podcast: https://youtu.be/vszypCVgpaE MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVH...

In this episode, we go into a study that investigates if alcohol affects our muscle growth potential by specifically looking at muscle protein synthesis, as well as some proxy markers of protein breakdown. Study: https://pubmed.ncbi.nlm.nih.gov/24533082/ Video Podcast: https://youtu.be/CaRPAx9gL4U MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/3...

This is an involved one, but if you care to join me as I explain my recent publication with my lab wherein we discover and describe a new pathway by which autophagy is mediated in cells, then you'll learn some cutting edge science. My Study: https://www.researchgate.net/publication/350870898_Parkin-independent_mitophagy_via_Drp1-mediated_outer_membrane_severing_and_inner_membrane_ubiquitination Vi...

This podcast gets really nitty gritty in that it discusses the intracellular signaling pathways and the association between smooth muscle cells and a protein rich foundation known as the extracellular matrix - what causes this weakness in the aorta of the vascular system leading to aneurysm formation? Find out. Study: https://youtu.be/YlQtTdj2eLo Video Podcast: https://youtu.be/YlQtTdj2eLo MY BOOK...

In this episode, we finish up from last week by discussing how mitochondrial "behavior" is affected by excessive exercise, as well as its impact on mitochondrial reactive oxygen generation, which can cause damage to our cells. Study: https://www.sciencedirect.com/science/article/abs/pii/S1550413121001029?via%3Dihub MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book...

In this episode, I cover a brand spankin' new study wherein the researchers attempt to answer the question of overdoing exercise and its impact on muscle mitochondria, as well as blood sugar regulation. Study: https://www.sciencedirect.com/science/article/abs/pii/S1550413121001029?via%3Dihub Books, Courses, and Hire Me: www.physionic.org YouTube: bit.ly/2JUjXVt Facebook: bit.ly/2PlIOaB Instagram:...

In this episode, we take a look at a study that investigates the impact weight loss/calorie restriction has on metabolic adaptation; we also briefly discuss the idea of metabolic "damage". This is one of a few episodes that I'll be using to cover the topic of metabolic adaptation. Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328781/?fbclid=IwAR3WSvSpNLzgnwfGh_xyAEx4Txh9z91LnjbW2CFrbbzSS0cM...

In this episode, I take us on a brief breakdown of a study looking at the ketogenic diet and its impact on heart cell death, heart size, and mitochondrial content. Some intriguing, potentially alarming, results here, but we'll see what interpretations we can really make on this data - dive in with me! Study: https://www.nature.com/articles/s41392-020-00411-4 Books, Courses, and Hire Me: www.physio...

In this episode, I attempt to make it as clear as possible, by comparison of high fat/keto to high carbohydrate diets and how they differ in their ability produce body fat loss, although one promotes greater fat burning/oxidation. Video Podcast (available at 10am ET): https://youtu.be/Ns0tXvLI-OI Books, Courses, and Hire Me: www.physionic.org YouTube: bit.ly/2JUjXVt Facebook: bit.ly/2PlIOaB Instag...

In this episode, I give a bit of a higher level view on metabolic flexibility - what is it? Why is it important? Instances of it? How to improve it? That's all covered in this podcast - enjoy! Books, Courses, and Hire Me: www.physionic.org YouTube: bit.ly/2JUjXVt Facebook: bit.ly/2PlIOaB Instagram: bit.ly/2OBFe7i Email List: bit.ly/2AXIzK6

In this episode, I briefly cover certain aspects of a study that looks into how effective fasting, specifically multi day water fasting, affects our mitochondrial content in our cells (muscle). Video Podcast: https://youtu.be/KMU1OcGjjLw Books, Courses, and Hire Me: www.physionic.org YouTube: bit.ly/2JUjXVt Facebook: bit.ly/2PlIOaB Instagram: bit.ly/2OBFe7i Email List: bit.ly/2AXIzK6

In this episode, I cover more detail on an experiment I decided to try on myself over the last 10 months wherein I try to maintain my muscle with minimal effort. I answer questions from 10 people who wrote questions out on how I pulled it off, as well as other questions related to fat loss and muscle perseveration. Video being Discussed [I Ran an Experiment on Myself]: https://youtu.be/qtim_tXkVoQ...

In this podcast, we'll be going over a presentation I gave in one of my courses on Muscle Biology - specifically, how certain mutations in a gene can impede muscle cells' ability to fuse, and on top of that, why some people survive it and why others do not. Study: https://www.nature.com/articles/ncomms16077 Books, Courses, and Hire Me: www.physionic.org YouTube: bit.ly/2JUjXVt Facebook: bit.ly/2Pl...

There is no human condition wherein you will be at peak form in multiple areas. Much like the idea of the generalist vs the specialist - your body can't be a specialist in all ways, and in the same vein, there is no diet that will be the "ultimate" diet that will help you achieve peak-ness in all areas. The discussion of lifespan vs health span is a great example of that, as well as the idea of gr...

In this content, I dive into a study looking into three hunger related hormones and the effect water fasting and calorie counting have, in obese and lean individuals, on three hunger hormones - leptin, melanocyte stimulating hormone (MSH), and Aguiti Related Protein (AgRP). Does fasting stimulate these hormones or does calorie counting? Does obesity play a factor? Find out! Study: https://pubmed.n...

In this episode, I discuss a molecule I ran across when listening to the Joe Rogan Experience. This molecule, known as fractalkine, has some unique characteristics and potential implications in a series of different diseases and brain related health outcomes - mostly related to inflammation in the brain. Review: https://pubmed.ncbi.nlm.nih.gov/26084002/ My Creatine Book and Course: http://bit.ly/3...

In this episode, we briefly discuss three ways that creatine positively affects us in muscle, the brain, and inflammation. I also introduce my first paid content that I spent most of 2020 working on, as well as a new website for your viewing pleasure - it was a busy 2020 for me! Creatine Book and Course: https://www.physionic.org/booksandcourses Books, Courses, and Hire Me: www.physionic.org...

In this episode, I go into a bit more detail on a topic I've just started releasing content on (in video form). This subject is on a hormone that also leads to fat storage, much like insulin, yet many keto espousing gurus either ignore or are not aware of it; this is convenient, since this hormone is stimulated by fat consumption, not carbohydrate consumption (the exact anti-thesis to insulin). Bo...

In this episode, we'll be diving head long into a study investigating the first slice of "chrono nutrition" on Physionic. I love this study, because they do several things really well and give us some clear answers regarding intermittent fasting and its impact on insulin sensitivity *independent* of calorie intake (finally!). Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528549/pdf/nqaa192....

In this podcast, I decided to jump into an area I've created a decent amount of isolated content and put it into one place. I go into a bit of depth, but not complete depth into three mechanisms of muscle growth - from the classic "muscle damage" to metabolic stress. Knowing this information can easily help us understand how to create training programs that aren't centered around old fashioned thi...

In this episode, we'll be diving into our third and final part of our "Nutrition on Depression" podcast wherein we'll be touching on depression's link in obesity, epigenetics, and the amino acid tryptophan (the same stuff found in turkey, and many other foods). Hopefully you find some, if not all, the information useful and informative. If you'd like to see the visuals, check out the video version...