This Week in Startups

This Week In Startups is made possible by: IM8 Health - IM8health.com/twist Sentry - Sentry.io/twist Deel - Deel.com/twist Plaud - https://Plaud.ai/twist What's the technology story of the year? No, it's not Anthropic's Mythos model, nor any other AI model. Upcoming IPOs? Wrong again. Jason thinks it's China's government's decision to block Meta's acquisition of Manus. The multi-billion-dollar dea...

This Week In Startups is made possible by: Northwest Registered Agent - https://northwestregisteredagent.com/twist LinkedIn Jobs - https://LinkedIn.com/twist Today's show: It's a News and Off-Duty weekend roundup! AngelList's USVC fund is open to anyone with $500, but it's getting pushback on social media. Do the critics have a point? A Special Forces soldier made $409K betting on the military's c...

This Week In Startups is made possible by: Northwest Registered Agent - https://northwestregisteredagent.com/twist Render - https://render.com/twist Agree - https://agree.com Ro - https://Ro.co/Twist Plaud - https://Plaud.ai/twist Today's show: The US military is running low on missiles, but now, Firehawk Aerospace is using 3D-printed solid rocket propellant to cut production costs in half and 5x...

This Week In Startups is made possible by: LinkedIn Jobs - linkedIn.com/twist Grasshopper Bank - grasshopper.bank/twist Notion - notion.com Today's show: This week, SpaceX announced that it was partnering with AI coding startup Cursor on new AI models. xAI's parent company is bringing compute, while Cursor brings developer market share and recent successes, training its own coding models. The deal...

This Week In Startups is made possible by: Quo - https://quo.com/TWiST Vanta - https://vanta.com/twist Pilot - https://pilot.com/twist Plaud - https://Plaud.ai/twist Today's show: *Eragon CEO Josh Sirota believes that you should "own your intelligence." He demos a live enterprise AI operating system connecting email, Slack, calendar, and financial data into a single agentic layer that's pre-traine...

This Week In Startups is made possible by:IM8 Health - https://IM8health.com/twist Grasshopper Bank - https://grasshopper.bank/twist Northwest Registered Agent - https://northwestregisteredagent.com/twist Plaud - https://Plaud.ai/twistToday's show:Is 3D printing the key to not just solving the housing crisis but bringing us all into a more beautiful and utopian future? ICON founder Jason Ballard t...

This Week In Startups is made possible by: LinkedIn Jobs - LinkedIn.com/twist Every.io - every.io Render - render.com/twist Today's show: *Imagine scrolling through mobile games the way your flip through your TikTok feed. What if you could build your own game in 90 seconds and share it with the world? That's what over 100,000 users are enjoying right now on Nanogram. On TWiST, we meet the co-found...

This Week In Startups is made possible by: Sentry - https://sentry.io/twist Deel - https://deel.com/twist Netsuite - https://netsuite.com/twist Plaud - https:// Plaud.ai/twist Today's show: *TAO just had its worst week since launch. One of Bittensor's most prominent subnet operators allegedly dumped $10 million in tokens and walked away. We're digging into what we know, how this could change the B...

This Week In Startups is made possible by: Pilot - https:// pilot.com/TWIST Squarespace - https:// squarespace.com/TWIST Northwest Registered Agent - https:// northwestregisteredagent.com/TWIST Plaud - https://Plaud.ai/twist CrowdHealth - ⁠https://JoinCrowdHealth.com/twist⁠ Today's show: TAO, the token associated with the Bittensor network, fell sharply last night after a major project declared it...

Anthropic just built a model so dangerous, they're not even going to release it (for now). On TWiST, Jason, Alex, and Neurometric CEO Rob May discuss whether or not this is just another frontier model or a potential weapon of mass internet destruction. Claude Mythos Preview is already in the hands of over 40 Anthropic partners — including Nvidia, Apple, Amazon, Microsoft, and Google — as part of i...

Anthropic just pulled the plug on Claude subscriptions for OpenClaw and every third party agentic tool. So Jason and Lon welcome back three of our top TWiST OpenClaw experts to break down what it means, how much it's going to cost now, and whether this is truly the end of the subsidized AI era. And they all brought demos! We're checking out ClawChief from Ryan Carson, Alex Finn's agent Henry, and...

This Week In Startups is made possible by: Deel - deel.com/twist Grasshopper Bank - grasshopper.bank/twist Render - render.com/twist Plaud - Plaud.ai/twist An AI "holding company" rebuilt dozens of YC Winter '26 startups in one weekend. Now we're bringing the founder responsible into Jason's Courtroom to defend himself. PLUS a live demo of Boardy, the AI that acts like a virtual board member and m...

This Week in AI, JCal sits down with three CEOs building the infrastructure, intelligence, and interfaces for the next era of AI: Jeremy Fraenkel (CEO, Fundamental), Victor Riparbelli (CEO, Synthesia), and Nick Harris (CEO, Lightmatter). We break down what's actually happening beneath the AI hype: the data modality LLMs completely missed, why copper is the real bottleneck in AI data centers, OpenA...

This Week In Startups is made possible by: PaperOS - https://PaperOS.com/twist Northwest Registered Agent- https://northwestregisteredagent.com/twist Every.io - https://Every.io Plaud - https:// Plaud.ai/twist Today's show: Silicon Valley just lined up its biggest liquidity event in years: SpaceX filed confidentially for an IPO that could target a $1.75 trillion valuation — potentially the largest...

This Week In Startups is made possible by: Quo - https:// quo.com/TWiST LinkedIn Jobs - https:// LinkedIn.com/twist Iru - https:// iru.com/twist Plaud - https:// Plaud.ai/twist Today's show: Google project manager Shubham Saboo is running 6 AI agents on a Mac Mini that handle all of his side business autonomously, from research, to social posts, to newsletters. He joins Jason and Lon to walk us th...

This Week In Startups is made possible by: Wispr Flow - https:// wisprflow.ai/twist Circle - http://circle.so/twist Deel - http:// deel.com/twist Today's show: AstroForge is building low-cost, replicable spacecraft to mine platinum group metals from near-Earth asteroids — a $60 billion annual market for materials that are running out on Earth. Founder and CEO Matt Gialich joins the show to talk ab...

This Week In Startups is made possible by: Luma AI - https:// lumalabs.ai/twist Every.io -  https:// every.io Lemon.io - https:// Lemon.io/twist Plaud - https:// Plaud.ai/twist Today's show: What do drug discovery, the creator economy, and AI vision models have in common? In the case of Metanova, Bitcast, and Score, the answer is Bittensor. Yes, each of the three companies leverages the Bittensor...

This Week in AI sneak peak! If you enjoy the episode find us on Spotify, Apple podcasts and YouTube by looking up "This Week in AI" or by going to thisweekinai.ai This week Jason sat down with Jake Loosararian and Chris Lattner on Episode 6 of This Week in AI. Jake is the CEO and co-founder of Gecko Robotics, a company deploying purpose-built robots and AI for mission-critical infrastructure inspe...

This Week In Startups is made possible by: Northwest Registered Agent - https://northwestregisteredagent.com/twist LinkedIn Jobs - https:// linkedIn.com/twist Sentry - https:// sentry.io/twist Plaud - http://Plaud.ai/twist Ro.co - http://Ro.co/Twist Today's show: Hustle Fund general partner Elizabeth Yin joined Jason and Alex to discuss how rapid advances in AI have changed the venture capital gam...

This Week In Startups is made possible by: Northwest Registered Agent - https:// www.northwestregisteredagent.com/twist Circle - https://circle.so/twist Netsuite - https://www.netsuite.com/twist Today's show: Zipline founder Keller Cliffton started his company with a simple premise: build automated logistics that serve everyone equally. The only problem? It was literally illegal in the US. In this...

This Week In Startups is made possible by: Deel - https:// deel.com/twist LinkedIn Jobs - https:// LinkedIn.com/twist . Iru - https:// iru.com/twist Today's show: We've got a treat for you today on TWiST! Jason is live from LAUNCH Fest in San Francisco, where he's joined by Robinhood founder Vlad Tenev. The era of AI is here. Robinhood found success in the midst of the last great technological shi...

This Week In Startups is made possible by: Caldera + Lab - https:// CalderaLab.com/TWIST Northwest Registered Agent - https:// northwestregisteredagent.com/twist Lemon - https:// Lemon.io/twist Today's show: Computers that read your mind? Jets that are all wings? Continuously tracking your body's vital signs to live longer? We've got all that and more on the show today. First, we sat down with the...

Legendary British ad man Rory Sutherland invented a fake business on a podcast, a coffee shop appealing to the busy commuter called "Flat White or F**k Off." But it's one thing to have a post go big on TikTok or Instagram… but to turn that viral moment into an actual COMPANY is a very different challenge. On TWiST, Jason and Lon chat with Charlie Hurst, Tom Noble, and Will Sudlow, founders of the...

This Week In Startups is made possible by: Circle - http://circle.so/twist Sentry - http:// Sentry.io Deel - http://deel.com/twist Plaud - http://Plaud.ai/twist Today's show: It's self-driving time! We're going deep on one of the most exciting spaces developing in the world, autonomous vehicles! We've got 3 experts on the show to talk to us enlighten us, Ben Seidl of Autolane, Ming Maa of Moove, a...

This Week In Startups is made possible by: Northwest Registered Agent - ⁠⁠northwestregisteredagent.com/twist⁠⁠ Quo - ⁠⁠quo.com/TWiST⁠⁠ Gusto - ⁠⁠Gusto.com/twist⁠⁠ Plaud - http://Plaud.ai/twist Athena - https://www.athena.com/jcal Today's show: How long until AI models can improve AI models? Once possible, recursive self-improvement by AI technology could accelerate — forever. Thus far, humans (and...