Basics to Brilliance: Haematology Podcast

Feedback Clinical Presentation Classifications of VWD ' Basics to Brilliance: Haematology Podcast' has been accredited for CPD credit by the Royal College of Pathologists UK.  Medical professionals and clinical scientists holding career-grade positions, who are registered with any of the Royal Colleges for CPD, will be eligible to earn 1 credit for every hour of learning.  Email: basicst...

Feedback ' Basics to Brilliance: Haematology Podcast' has been accredited for CPD credit by the Royal College of Pathologists UK.  Medical professionals and clinical scientists holding career-grade positions, who are registered with any of the Royal Colleges for CPD, will be eligible to earn 1 credit for every hour of learning.  Email: basicstobrilliancehaem@gmail.com Insta: BasicstoBril...

Feedback Haider steps out of the shadows.... Make sure you send us the questions you're too afraid to ask your haem reg (or consultant) - email address below! ' Basics to Brilliance: Haematology Podcast' has been accredited for CPD credit by the Royal College of Pathologists UK.  Medical professionals and clinical scientists holding career-grade positions, who are registered with an...

Feedback We are delighted to have Dr. Noémi Roy  Consultant Haematologist at Oxford University Hospitals NHS Foundation Trust  join us for this very special episode! ' Basics to Brilliance: Haematology Podcast' has been accredited for CPD credit by the Royal College of Pathologists UK.  Medical professionals and clinical scientists holding career-grade positions, who are registered with...

Feedback Welcome to the Red Cell Series! Timestamps and notes to follow... ' Basics to Brilliance: Haematology Podcast' has been accredited for CPD credit by the Royal College of Pathologists UK.  Medical professionals and clinical scientists holding career-grade positions, who are registered with any of the Royal Colleges for CPD, will be eligible to earn 1 credit for every hour of lear...

Feedback Timestamps to follow! ' Basics to Brilliance: Haematology Podcast' has been accredited for CPD credit by the Royal College of Pathologists UK.  Medical professionals and clinical scientists holding career-grade positions, who are registered with any of the Royal Colleges for CPD, will be eligible to earn 1 credit for every hour of learning.  Email: basicstobrilliancehaem@gmail.c...

Feedback This is a discussion about possible factors and strategies to consider and should not be used as a guideline for clinical practice. Always discuss complicated cases with the attending H&T consultant. 00:52 Intro 01:30 Case 1: 41M Severe Haemophilia A, acute MI needing PCI Try the 4 steps! Bleeding Risk Anticoagulant characteristics Intensity of anticoagulant (prophylactic vs therapeut...

Feedback 00:52 Intro and chuckles 01:40 Case study: 75M, left calf swelling, put on DOAC, 24 hrs later haematoma and deep bleed on CT 06:00 General information Elderly (>65), Mortality 8-40% Common presentations: GI and UG bleeding, Retroperitoneal and muscle bleeds (compartment syndrome) Ptegnancy, TTP, Malignancy (15%), Autoimmune disease (17%) 08:56 Pathogenesis and diagnosis: AutoAb against...

Feedback 00:52 Intro - very important topic 02:00 Case Study: Haem/Obstetrics clinic, Family Hx Severe Haemophilia A, 12wks pregnant 04:15 Clotting changes in pregnancy Increased: FVII, FVIII, FX, VWF, Fibrinogen Decreased: FXIII   Protein S, Antithrombin  Stable: FIX 07:57 New born to 6 months clotting: FVIII (8) similar to adult FIX (9) lower and rises after 6 months 09:30 GUEST STARRING Dr. Wil...

Feedback 00:52 Intro 02:10 Definition Common: Alloantibody neutralizes FVIII Rare: causes increased clearance of FVIII 1/3 of Severe Haemophilia A patients Median time 10-15 emergency doses RF: Mutation types (INSIGHT study), <5 or >60, African/Hispanic, HIVneg, large rFVIII doses, FVIII + inflammatory stimulus 07:05 Inhibitor classifications Titres: Low (<5 BU) vs. High (>5 BU) Respon...

Feedback 00:52 Intro 02:35 Structure of Haemophilia A care 05:10 Key aspects of management (On-demand vs prophylaxis) 07:00 Prophylaxis: reduce death rates from ICH and reducing joint bleeds - Primary prophylaxis: before the 2nd joint bleed Severe haemophilia Any child spontaneous ICH Moderate haemophilia A (1-3 IU/dL) - Secondary prophylaxis: After the 2nd joint bleed Limit joint damage and maxim...

Feedback 00:52 Intro 02:00 What is Haemophilia A? 03:00 Factor VIII, Pathogenesis of Haemophilia A 07:10 Structure of Factor VIII (exam pearl) 300kD Heavy (A1 A2, B) + Light Chain (A3, C1, C2) bound by a metal ions *Calcium* A subunits are 30% homologous B subunit (variable region) is cleaved by thrombin to get Factor VIIIa C1 and C2 help bind to VWF Good to r/o VWF 10:55 Epidemiology and history...

Feedback 01:45 Case: Neonate with repeated umblical bleeding. IC haemorrhage.  Normal Factors (so far), Normal VW screen, Normal FBC and normal film. 05:35 Factor XIII (13): function and presentations in deficiency  09:45 Testing, testing!  ELISA/Ammonia Release Assay then a Mutational Analysis  Honarable mention: Clot Solubility Assay 16:00 Fibrinolysis definition and pathway 21:00 Activators of...

Feedback 00:52 Intro: definition and prompts 04:25 Intro to Case 1: Haemophilia B, 3rd dose of BeneFix Anaphylaxis  06:03 Intro to Case 2: Severe Haemophilia A, joint bleed, non-responsive to emergency Factor VIII 07:30 Initial screening tests  NB: Inhibitors: Time Dependent vs. Immediate Acting 14:54 Flash examples of Mixing Study importance 16:35 Bethesda Assay  **Bethesda Studios made the Elder...

Feedback 00:52 Intro (shoutuout to the BSH anticoagulant monitoring guidelines) 02:15 Practical relevance of testing and monitoring anticoagulants  07:30 Heparin: The Basics  09:00 Unfractionated Heparin vs. Low Molecular Weight Heparin  10:24 Mechanism of action of Heparin (UfH vs. LMWH) LMWH: more Anti-Xa activity UfH Anti-IIa acitivity = Anti-Xa activity 15:30 Pharmacokinetic differences (UfH v...

Feedback 00:54 Intro and table of contents 1:48 Case 1: pre-op, prolonged PT and ++ prolonged APTT…thrombin time done 03:44 Case 2: post-op, normal PT and prolonged APTT…thrombin time done 04:46 Thrombin Time definition and ingredients (its all about the fibrinogen!) 10:45  Differentiating causes of prolonged thrombin time- protamine, reptilase, ecarin 17:24 Case 3: Major Haemorrhage (Variceal), d...

Feedback 0:52 Intro and table of contents 2:36 CASE 1- Infection, due surgery and a prolonged APTT  ft. a refresher on APTT prolongation 08:00 Mixing studies- definition and uses ft. Hari’s exam nugget 17:00 Factor assays (1 stage, 2 stage and chromogenic assays) ft. David’s humorous humility 43:30 David applies his new-found knowledge to our first case 45:45 CASE 2-  Infection, hx of weight loss...

Feedback ' Basics to Brilliance: Haematology Podcast' has been accredited for CPD credit by the Royal College of Pathologists UK.  Medical professionals and clinical scientists holding career-grade positions, who are registered with any of the Royal Colleges for CPD, will be eligible to earn 1 credit for every hour of learning.  Email: basicstobrilliancehaem@gmail.com Insta: BasicstoBril...

Feedback 00:00 Intro 04:25 Automated Methods of Measuring a Clot 05:50 Scenario 1 & Pre-Analytical Variables 11:50 HIL Index & Patient Factors 15:55 Blood Tube Basics 21:10 Nitty Gritties- What Happens When We Send a PT? 23:20 PT vs INR for Warfarin- Going Down The Rabbit Hole... 26:35 Heparin Neutralising Buffer 29:00 APTT  33:05 Summary (& an honorable mention) ' Basics to Brill...

Feedback 0:00 Intro 2:45 What is Haemostasis? 3:55 Stages of Haemostasis (summary) 4:45 Primary Haemostasis  8:35 Secondary Haemostasis 11:10 The Clotting Cascade 12:20 Common + Extrinsic Pathway 13:50 Intrinsic Pathway (TwelvEleveNinEight) 14:25 Clotting Tests 16:30 Hari Pops The Bubble 18:05 In-Vivo vs. In-Vitro 22:20 Isolated PT Prolongation- causes 25:46 Isolated APTT Prolongation- causes 27:4...

Feedback ' Basics to Brilliance: Haematology Podcast' has been accredited for CPD credit by the Royal College of Pathologists UK.  Medical professionals and clinical scientists holding career-grade positions, who are registered with any of the Royal Colleges for CPD, will be eligible to earn 1 credit for every hour of learning.  Email: basicstobrilliancehaem@gmail.com Insta: BasicstoBril...

Feedback ' Basics to Brilliance: Haematology Podcast' has been accredited for CPD credit by the Royal College of Pathologists UK.  Medical professionals and clinical scientists holding career-grade positions, who are registered with any of the Royal Colleges for CPD, will be eligible to earn 1 credit for every hour of learning.  Email: basicstobrilliancehaem@gmail.com Insta: BasicstoBril...

Feedback ' Basics to Brilliance: Haematology Podcast' has been accredited for CPD credit by the Royal College of Pathologists UK.  Medical professionals and clinical scientists holding career-grade positions, who are registered with any of the Royal Colleges for CPD, will be eligible to earn 1 credit for every hour of learning.  Email: basicstobrilliancehaem@gmail.com Insta: BasicstoBril...

Feedback Polycythaemia-  red cell # Erythrocytosis – in red cell mass Absolute Erythrocytosis - M: Hct >0.60 or >0.52 + RCM >25% of mean - F: Hct >0.56 or >0.48 + RCM >25% of mean Apparent Erythrocytosis - Men: Hct >0.52 + normal RCM - Women: Hct >0.48 + normal RCM Relative erythrocytosis -Normal RCM + Reduced plasma volume (pathological dehydration) M>F Median >60yo...

Feedback -       Synchronous CNS and systemic lymphoma at initial presentation (treatment-naïve; TN-SCNSL ) -        CNS relapse without recurrent systemic lymphoma (relapsed isolated CNS lymphoma; RI-SCNSL ) -        Relapsed concomitant systemic and CNS disease following treatment for systemic lymphoma (RC-SCNSL )  Generally hybrid disease  Investigations -  MRI Head w gadolinium -  PET-CT -  Te...