Authentic Biochemistry

Dr. Guerra focuses on emerging  signaling and immunoepigenetic  variations around the theme of protease inhibitor mediation of various stages and forms of solid organ and metastatic tumorigenesis in this June 29,2019 installment of Authentic Biochemistry.

Dr Dan Guerra reveals that serine protease inhibitors (Serpins) are endogenous proteins that block protease-mediated metastasis and cancer associated fibroblast activation in some tumor microenvironments but not all. The myriad 'labyrinth' interactions among cytokines , proteases, protease inhibitors and the dysregulation of the T-lymphocytic immune response obtains a confounding pharmacotherapeut...

Dr. Guerra of Authentic Biochemistry provides a primer on polypeptide  proteases and their mode of action as well as their control via processing and  inhibition in clinical medicine

Serine proteinases and their peptide inhibitors, the SERPINS, have a role to play in liver pathology and disease  potentiation leading to subcellular protein aggregation, enhanced  inflammation and ultimate hepatocellular carcinoma. Dr. Guerra of Authentic Biochemistry introduces this new plank in the knowledge platform being constructed to apprehend either the necessary or sufficient co...

In this segment I provide more discussion of the published evidence linking glycolytic pathway enzymes to HCC progression. The expression of certain interfering RNA's that differentially regulate gene expression and promoter habilitation can lead to cyclin dependent kinase mediated chromatin remodeling enhancing cell -specific expression of enzyme isoforms that promote rather than defeat disease p...

Dr. Guerra of Authentic Biochemistry continues with the 4th in a series of HCC lectures from the primary research literature by explaining the interacting roles of pyruvate kinase M2 and phosphofructokinase 2 promote aerobic glycolysis-enhancing cancer progression.

Authentic Biochemistry's host, Dr Dan Guerra, continues his in depth cellular and molecular discussion of hepatocellular carcinoma (HCC) by introducing the non-universal yet a priori role for  the glycolytic enzyme pyruvate kinase isoform M2 in paradigmatic tumor associated aerobic glycolysis. 

Dr Guerra takes a deeper dive into the hormonal and subcellular dysfunctional arrays linking obesity to Non-alcoholic Steatohepatitis (NASH) and Hepatocellular Carcinoma 

This is Part One of what will be a 3-5 part sequence of podcast lectures giving Authentic Biochemical discussion concerning  the links between obesity , sedentary lifestyle, alcohol consumption and inflammatory diseases of the liver that may lead to the high mortality cancer, Hepatocellular Carcinoma. 

Because HDAC4 closely resembles the structural component of the superfamily of histone deacetylases,  in might be assumed it functions to catalyze the removal of LYS bound acetate. But since HDAC4 does not contain the catalytically necessary TYR-OH but rather an HIS-imidizole it has no deacetylase enzymatic activity. However HDAC4 does interact with other proteins and the net result is protec...

Dr Daniel Guerra or VerEvMed and AB podcast provides the second part of his discussion concerning excitotoxic glutamate inducing aSMASE mediated neurodegeneration involving iron and the depletion of the glutathione-ROS- scavenging system in damaged and diseased oligodendrocytes. 25March2019B

This is the first part of a diaeventontological framing of lipid peroxidative mechanisms for CNS neurodegeneration. Dr Guerra describes recent published research  (JLR 2018 .59:312pp.) and develops some of the key elements of the ferroptosis programmed cell death mechanism leading to  oligodendrocyte and neuronal degeneration that will participate in a grander understanding of injury-ind...

In this podcast, Dr Daniel Guerra of Authentic Biochemistry and VerEvMed endeavours to examine the  bioenergetic and pro-inflammatory prodromal  patho-biochemistry of age-onset Alzheimer's Disease using his diaeventontological toolkit.

Dr. Daniel J.  Guerra introduces his paradigmatic shift for understanding biochemical phenomena as prolegomena to understanding Alzheimer's Disease.

Dr Daniel Guerra of Authentic Biochemistry in his initial podcast introducing the show and starting off with initial content on current  Alzheimer's Disease research