Aging-US

Rare genetic disorders that cause features of aging to appear much earlier than expected can offer an unusual window into the biology of human aging. Yet information about these conditions is scattered across publications and databases, and the same genes or syndromes are sometimes described using different terminology. A new study brings much of this information together in a manually curated gen...

BUFFALO, NY — October 13, 2026 — A new #research paper was #published in Volume 18 of Aging on September 16, 2026, titled “Targeting phospholipase Pla2g15 reduces long-chain BMP phospholipids abundance and senescence in kidney cells.” The study found that disrupting the gene Pla2g15 reduced stress-induced cellular senescence in mouse kidney cells while altering the composition of phospholipids inv...

BUFFALO, NY — October 8, 2026 — A new #commentary was #published in Volume 18 of Aging on September 12, 2026, titled “Complexity, variability, and the behavioral layer of gerophysics: a commentary on Unfried et al. (2026).” The commentary proposes expanding the emerging field of gerophysics to include behavioral complexity, offering a way to understand how aging affects the ability to adapt to eve...

BUFFALO, NY — October 6, 2026 — A new #research paper was recently #published in Volume 18 of Aging, titled “Spatially fractionated mini-GRID radiotherapy differentially modulates radiation-induced senescence in murine glioma and normal cells.” The study found that spatially fractionated mini-GRID radiotherapy reduced several features of radiation-induced cellular senescence in two glioma cell lin...

BUFFALO, NY — October 5, 2026 — Aging is pleased to support the 11th International Cell Senescence Association (ICSA) Conference, taking place November 3–5, 2026, at Seoul National University’s Siheung Convention Center in South Korea. The conference will bring together researchers from around the world to advance understanding of cellular senescence and its roles in aging, cancer, health, and dis...

BUFFALO, NY — October 1, 2026 — A new #research paper was #published in Volume 18 of Aging on September 10, 2026, titled “Social determinants of health and risk of dementia in people with and without type 2 diabetes – findings from two large national-scale cohorts.” The study found that unfavorable social determinants of health (SDOH) were associated with a higher risk of dementia in adults with a...

Aging is commonly associated with the gradual loss of skeletal muscle mass and function. While preserving muscle mass is important, muscle health also depends on the mitochondria that provide energy for contraction and help muscles respond to physical stress. A new study suggests that a protein called Activating Transcription Factor 5 (ATF5) plays a complex role in balancing these processes during...

BUFFALO, NY — September 29, 2026 — A new #review was #published in Volume 18 of Aging on September 8, 2026, titled “Developmental senescence misregulation in congenital disorders: CHARGE syndrome as a candidate model.” The article proposes that disruption of developmental senescence—a tightly controlled cellular program involved in embryonic tissue remodeling—may contribute to congenital abnormali...

In this episode of the Longevity & Aging Series (S4, E6), Dr. Adam Bohnert from the Department of Biological Sciences at Louisiana State University (Baton Rouge, LA) joins host Dr. Yuan Zhao to discuss the research paper he co-authored in Volume 18 of Aging, titled “Inhibition of peroxisomal protein PRX-11 promotes longevity in Caenorhabditis elegans via enhancements to mitochondria.” DOI - https:...

BUFFALO, NY — September 24, 2026 — A new #review was #published in Volume 18 of Aging on September 8, 2026, titled “How to live for centuries: common denominators of organisms with exceptional longevity.” The review examines what some of the world’s longest-lived organisms may reveal about the biology of exceptional longevity. The review was led by first author Stefania E. Kapsetaki from the Insti...

BUFFALO, NY — September 21, 2026 — A new #review was #published in Volume 18 of Aging on August 31, 2026, titled “The guardian paradox: DNA damage response overactivation as an integrative driver of aging – a tumor suppressor–negative regulator framework.” The review presents a new framework proposing that chronic overactivation of the DNA damage response (DDR) may serve as a major integrating dri...

A research paper recently published in Aging, titled “Human-relevant Ptpn6 mutation alters immune and hepatic functions during aging,” investigated how a human-relevant mutation in the PTPN6 gene, which encodes the immune and metabolic regulator SHP-1, affects immune and liver function during aging. Using mice carrying the mutation, the researchers found that older mutant mice had improved glucose...

BUFFALO, NY — September 16, 2026 — A new #research paper was #published in Volume 18 of Aging on August 28, 2026, titled “Human-relevant Ptpn6 mutation alters immune and hepatic functions during aging.” The study examines how a mutation affecting the immune and metabolic regulator SHP-1 reshapes liver function during aging, revealing that improved glucose metabolism can coexist with immune-cell ac...

BUFFALO, NY — September 14, 2026 — A new #review was #published in Volume 18 of Aging on August 26, 2026, titled “Assessing mechanisms and evidence of a causal role for cellular senescence and somatic mutations in aging.” The review examines two biological processes strongly associated with aging—cellular senescence and somatic DNA mutations—and evaluates whether the evidence supports their causal...

Scientific progress often begins with questioning assumptions that have shaped a field for decades. Few researchers embodied this approach as strongly as Dr. Mikhail “Misha” Blagosklonny, an oncologist and biogerontologist whose unconventional theories challenged traditional explanations of why organisms age. An essay published in Volume 18 of Aging titled “Misha Blagosklonny: a life of ideas,” re...

BUFFALO, NY — September 10, 2026 — A new #research paper was #published in Volume 18 of Aging on August 24, 2026, titled “Disruption of the insulin/IGF-1 signaling pathway in Caenorhabditis elegans dramatically increases male longevity and enhances reproductive health late in life.” The research was conducted by Rose S. Al-Saadi, Hannah B. Lewack and Patrick C. Phillips. Al-Saadi and Lewack contri...

BUFFALO, NY — September 9, 2026 — A new #research paper was #published in Volume 18 of Aging on August 13, 2026, titled “Protective effects of three herbal extracts on mitochondrial dysfunction in VPS13C-knockdown SH-SY5Y cells: implications for Parkinson’s disease.” The study was led by co-first authors Yih-Ru Wu and Chih-Hsin Lin from the Chang Gung Memorial Hospital, Chang Gung University Colle...

Dr. Falak Pahwa, Dr. Ranjan Kumar Nanda, and Mr. Ashish Gupta from the International Centre for Genetic Engineering and Biotechnology (ICGEB) in New Delhi, India, discuss their research paper, recently published in Volume 18 of Aging, titled “Host immunosenescence compromises Mycobacterium tuberculosis clearance.” Video interview - https://www.youtube.com/watch?v=bSaJaB751kM DOI - https://doi.org/...

BUFFALO, NY — September 3, 2026 — A new #research paper was published in Volume 18 of Aging on August 12, 2026, titled “Indy reduction decreases aging-related dysbiosis in Drosophila.” The study was led by first author Danielle N. A. Lesperance from the University of Connecticut. Corresponding authors Blanka Rogina and Nichole A. Broderick are affiliated with the University of Connecticut Health a...

Why do we age? For decades, one of the dominant explanations has been that cells and tissues gradually accumulate molecular damage until they can no longer function normally. DNA mutations, damaged proteins, mitochondrial dysfunction, epigenetic alterations, and other forms of cellular wear have all been proposed as major drivers of aging. But another theory offers a very different possibility: so...

BUFFALO, NY — August 31, 2026 — A new research paper was published in Volume 18 of Aging on August 11, 2026, titled “TMAO is associated with higher age, cardiometabolic risk factors and degenerative alterations of the brain in healthy elderly adults.” The study was led by first author Gunter Almer from the Clinical Institute of Medical and Chemical Laboratory Diagnostics at the Medical University...

BUFFALO, NY — August 26, 2026 — A new #review was #published in Volume 18 of Aging on August 10, 2026, titled “Metformin at the convergence of aging and longevity.” The review was authored by Jarra Manneh, May Alasmar and Nady El Hajj from the College of Health and Life Sciences at Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar. Corresponding author Nady El Hajj is also affiliated wit...

BUFFALO, NY — August 24, 2026 — A new research paper was published in Volume 18 of Aging on August 8, 2026, titled “Investigating POLG-driven modulation of cancer stemness: a pilot study in breast cancer cells.” The study was led by first author Chiara Chinigò from the Italian National Research Center on Aging (IRCCS INRCA), Cosenza, Italy. Corresponding authors Federica Sotgia and Michael P. Lisa...

BUFFALO, NY — August 24, 2026 — Aging is pleased to announce its partnership as a media partner of the 13th Aging Research and Drug Discovery Meeting (ARDD), taking place October 1–3, 2026, at the David Rubenstein Treehouse at Harvard University in Boston, Massachusetts. ARDD brings together leading researchers, clinicians, biotech innovators and industry experts to advance the understanding of ag...

A #Research paper recently #Published in Volume 18 of Aging, titled “Slowing intervertebral disc aging in mice through long-term systemic treatment with the senolytic BCL-2/BCL-xL proteolysis targeting chimera (PROTAC) 753b,” examines whether the senolytic PROTAC 753b can slow age-related intervertebral disc degeneration (IDD) in mice. Long-term systemic treatment with 753b reduced key features of...