This Week in Virology

Hosts:  Vincent Racaniello ,  Alan Dove , and  Rich Condit The sternutating TWiVers discuss preventing infection of cells and animals by a soluble CD4-CCR5 molecule that binds to HIV-1 virus particles. Links for this episode Dif-tor heh smusma  (NY Times) Immunization  preterm premature infants  (Thanks, Johnye!) HIV and SHIV protection conferred by  eCD4-Ig  (Nature) Tyrosine  sulfation  (Wikiped...

Host:  Vincent Racaniello Guests:  Rollie Clem  and  Lorena Passarelli Vincent visits the 'Little Apple' and speaks with Rollie and Lorena about their work on mosquito-born viruses and baculoviruses. Links for this episode Apoptosis inhibition  in  A. aegypti  (Apop) Initiator caspase  in armyworm (Insect Bioc Mol Biol) Manipulating apoptosis  in  A. aegypti  (J Virol) Viral inhibitors  of apoptos...

Hosts:  Vincent Racaniello ,  Dickson Despommier ,  Alan Dove ,  Rich Condit , and  Kathy Spindler Guest:  Lee Feinman Lee joins the TWiV team to discuss the value of post-doctoral training, and how a cellular microRNA assists in the replication of hepatitis C virus. Links for this episode Spin  by Robert Charles Wilson Immunization of  preterm infants  (Dev Period Med) miR-122 alters HCV  transla...

Hosts:  Vincent Racaniello ,  Dickson Despommier ,  Alan Dove , and  Kathy Spindler The family  TWiVidae  discuss changes in the human fecal virome associated with Crohn's disease and ulcerative colitis. Links for this episode Enteric virome  changes in inflammatory bowel disease (Cell) Gov. Christie  stumbles on vaccination  (NY Times) Anti-vax  psychology  (NPR) Vaccine skeptic  changes her mind...

Hosts:  Vincent Racaniello ,  Dickson Despommier ,  Alan Dove , and  Kathy Spindler The TWiVodes answer listener email about hantaviruses, antivirals, H1N1 vaccine and narcolepsy, credibility of peer review, Bourbon virus, influenza vaccine, careers in virology, and much more. Links for this episode Bourbon virus  (NY Times) Thogotovirus  (ViralZone) Drug induced apoptosis  and HIV infection (PLoS...

Hosts:  Vincent Racaniello ,  Dickson Despommier ,  Alan Dove , and  Kathy Spindler Guest:  Paul Duprex Paul joins the TWiV team to discuss the current moratorium on viral research to alter transmission, range and resistance, infectivity and immunity, and pathogenesis. Links for this episode Wain-Hobson objects ( one ,  two ,  three ,  four ) Influenza H7N1  transmission  experiments (J Virol) Epi...

Host:  Vincent Racaniello Guest:  John Coffin Vincent speaks with John Coffin about his career studying retroviruses, including working with Howard Temin, endogenous retroviruses, XMRV, chronic fatigue syndrome and prostate cancer, HIV/AIDS, and his interest in growing cranberries. Links for this episode John Coffin  (Wikipedia) Specific  HIV integration sites  (Science) Novel retrovirus in  moder...

Hosts:  Vincent Racaniello ,  Dickson Despommier ,  Alan Dove ,  Rich Condit , and  Kathy Spindler The TWiVers review the outcomes of two recent phase 3 clinical trials of a quadrivalent dengue virus vaccine in Asia and Latin America.   Links for this episode Efficacy of  dengue vaccine  (NEJM) Preventing  dengue (NEJM) Dengue  viruses (Scitable) Intention to treat  (Wikipedia) Image credit:  Jean...

Hosts:  Vincent Racaniello ,  Alan Dove ,  Rich Condit , and  Kathy Spindler The TWiV gang reviews ten fascinating, compelling, and riveting virology stories from 2014.   Ten virology stories of 2014 Ebola virus outbreak (TWiV  314 ,  309 ,  308 ,  307 ,  306 ,  305 ,  304 ,  303 ,  302 ,  298 ,  297 ,  283 ) Directional uncoating of rhinovirus RNA (TWiV  267 ) Pandemic pathogen controversy (TWiV ...

Host:  Vincent Racaniello Guests: Eurico Arruda, Gustavo Acrani, Cintia Bittar, Tatiana Domitrovic, and Suellen Galvino-Costa On his second trip to Brazil, Vincent joins Eurico to speak with three young virologists, Gustavo, Cintia, Tatiana, and Suellen, about their work and their prospects for careers in science. Video of this episode: view at  YouTube Send your virology questions and comments (e...

Hosts:  Vincent Racaniello ,  Alan Dove ,  Rich Condit , and  Kathy Spindler Vincent, Alan, Rich and Kathy discuss how interleukin 10 modulation of Th17 helper cells contribute to alphavirus pathogenesis. Links for this episode IL10 modulation of Th17 cells  during alphavirus pathogenesis (PNAS) Th17 cells involved in  influenza mediated gut injury  (J Exp Med) Helper T cells 2014-15 flu season  (...

Hosts:  Vincent Racaniello ,  Alan Dove ,  Rich Condit , and  Kathy Spindler Vincent, Alan, Rich and Kathy association of a virus with sea star melting disease, and the finding of a phycodnavirus in the oropharynx of humans with altered cognitive functions. Links for this episode National Influenza Immunization Week  (CDC) Densovirus associated with  sea star wasting disease  (PNAS) A virus that ...

Host:  Vincent Racaniello Guests:  Kartik Chandran ,  Ganjam Kalpana , and  Margaret Kielian Vincent travels to Albert Einstein College of Medicine where he speaks with Kartik, Ganjam, and Margaret about their work on Ebolavirus entry, a tumor suppressor that binds the HIV-1 integrase, and the entry of togaviruses and flaviviruses into cells. Links for this episode Antibodies that protect against ...

Hosts:  Vincent Racaniello ,  Alan Dove , and  Rich Condit Vincent, Alan, and Rich discuss how norovirus, an enteric virus, can replace the functions of the gut microbiome. Links for this episode Ebola virus  update  (WHO) Norovirus can replace functions of  gut microbiome  (Nature) Post-vaccinal  distemper encephalitis  (N Z Vet J) Novel sea otter  poxvirus  (J Wildl Dis) Poliovirus  escapes anti...

Hosts:  Vincent Racaniello ,  Dickson Despommier ,  Alan Dove ,  Rich Condit , and  Kathy Spindler The TWiVbolans discuss the finding that human noroviruses, major causes of gastroenteritis, can for the first time be propagated in B cell cultures, with the help of enteric bacteria. This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai....

Host:  Vincent Racaniello Guests:  Zhen Fu  and  Biao He Vincent visits the University of Georgia where he speaks with Zhen Fu and Biao He about their work on rabies virus and paramyxoviruses. Links for this episode Blood-brain permeability and rabies  survival  (Antiviral Res) Rabies induces  blood-brain permeability  (J Virol) Virus neutralizing antibodies in CNS of  non-lethal rabies  (PLoS Neg...

Hosts:  Vincent Racaniello  and  Glenn Rall Guest:  Ann Skalka Vincent and Glenn meet up with Ann and talk about her long and productive career in virology, from biochemistry to bacteriophage lambda to retroviruses.   Links for this episode Skalka  laboratory Asilomar Conference on  recombinant DNA Unexpected  inheritance (PLoS Path) Viral sequences in  vertebrate genomes  (J Virol) Assembly of  i...

Hosts:  Vincent Racaniello ,  Dickson Despommier ,  Alan Dove ,  Rich Condit , and  Kathy Spindler The TWiVocytes answer questions about Ebola virus, including mode of transmission, quarantine, incubation period, immunity, and much more. This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centra...

Host:  Vincent Racaniello Guest:  Tom Solomon Tom talks with Vincent about viral central nervous system infections of global importance, Ebola virus, and running the fastest marathon dressed as a doctor.   Links for this episode World's biggest brain Tom's  YouTube channel Sex, drugs, and emerging viruses  (TedX) The Running Mad Professor Image credit:  ClickLiverpool Video of this episode - view ...

Hosts:  Vincent Racaniello ,  Alan Dove , and  Kathy Spindler Guest:  Tara C. Smith Tara Smith joins the TWiEBOVsters to discuss the Ebola virus outbreak in west Africa, spread of the disease to and within the US, transmission of the virus, and much more.   This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virol...

Hosts:  Vincent Racaniello ,  Alan Dove , and  Kathy Spindler The Grand Masters of the TWiV discuss Ebola virus transmission, air travel from West Africa, Ebola virus infectivity on surfaces, the Dallas Ebola virus patient, and Ebola virus in dogs. This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs,...

Hosts:  Vincent Racaniello ,  Alan Dove , and  Kathy Spindler Vincent, Alan, and Kathy continue their coverage of the Ebola virus outbreak in West Africa, with a discussion of case fatality ratio, reproductive index, a conspiracy theory, and spread of the virus to the United States. This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai....

Hosts:  Vincent Racaniello ,  Dickson Despommier ,  Alan Dove , and  Kathy Spindler Guest:  Jeff Shaman The TWiV team consults an epidemiologist to forecast the future scope of the Ebola virus epidemic in West Africa.  This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one buildi...

Hosts:  Vincent Racaniello ,  Dickson Despommier ,  Alan Dove , and  Kathy Spindler The TWiV team discusses transmission of Ebola virus, and inhibition of Borna disease virus replication by viral DNA in the ground squirrel genome. This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized i...

Hosts:  Vincent Racaniello ,  Dickson Despommier ,  Alan Dove ,  Rich Condit , and  Kathy Spindler The TWiVers discuss the growing Ebola virus outbreak in West Africa, and an epidemic of respiratory disease in the US caused by enterovirus D68. Links for this episode Cancer patient saved by  measles virus Ebola virus  genome sequences  (Science) Robert Garry  on Ebola outbreak Aerosol transmission...