This Week in Virology

In his weekly clinical update Dr. Griffin discusses vaccine effectiveness against influenza illness in children, clinical manifestations of infection with poliovirus, spike protein-independent attenuation of SARS-CoV-2 Omicron variant in laboratory mice, concordance of SARS-CoV-2 results in self-collected nasal swabs vs swabs collected by health care workers in children and adolescents, probable a...

TWiV reviews the genetic characterization of a new strain of type 2 oral polio vaccine and its implications for eradication, and how a polymorphism in humans comprising a single amino acid change in an antibody molecule regulates vaccine elicitation of broadly neutralizing antibodies against influenza virus HA. Hosts:  Vincent Racaniello , Dickson Despommier , Alan Dove , Kathy Spindler , and Bria...

In his weekly clinical update Dr. Griffin discusses antibody response against nonpoliovirus enteroviruses, clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain, object and surface contamination with monkeypox virus, monkeypox virus infection in humans across 16 countries, clinical characteristics of ambulatory and hospitalized patients with monkeypox v...

Andy Slavitt joins TWiV to discuss his book, Preventable and how failures in leadership, politics, and selfishness doomed the U.S. response to SARS-CoV-2. Hosts:  Vincent Racaniello , Dickson Despommier , Kathy Spindler , and Brianne Barker Guest: Andy Slavitt Subscribe (free):  Apple Podcasts ,  Google Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episode In the Bubble podcas...

In his weekly clinical update Dr. Griffin discusses the public health response to a polio case in a unvaccinated NY state resident, human to dog transmission of monkeypox virus, Tecovirimat and the treatment of monkeypox, detection of asymptomatic monkeypox virus infections among male sexual health clinic attendees in Belgium, what to do if you are exposed to SARS-CoV-2 and isolation and precautio...

Michael Merchlinsky joins TWiV to discuss the development of two smallpox antiviral drugs and two smallpox vaccines and their uses during the monkeypox outbreak. Hosts:  Vincent Racaniello , Dickson Despommier , Rich Condit , and Kathy Spindler Guest: Michael Merchlinsky Subscribe (free):  Apple Podcasts ,  Google Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episode Michael o...

In his weekly clinical update Dr. Griffin discusses guidance for prevention and treatment of monkeypox, post-infectious symptoms among children and adolescents, profiling post-infectious syndromes of different variants, comparison of vaccine Ankara vs intradermal routes of administration, infection in vaccinated individuals treated with or without PAXLOVID, duration of symptoms with positive rapid...

TWiV discusses monkeypox virus, poliovirus in NY, Marburg virus in Ghana, ancient herpes simplex virus type 1 genomes, and immunogenicity of different combinations of SARS-CoV-2 vaccines. Hosts:  Vincent Racaniello , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free):  Apple Podcasts ,  Google Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episode Ho...

In his weekly clinical update Dr. Griffin discusses Tecovirimat for treatment of monkeypox, the safety and acceptance of vaccination after multisystem inflammatory syndrome, variants in solid organ transplant recipients, masks for prevention of respiratory virus infections, pre-exposure prophylaxis with Evusheld, the association between Evusheld administration and infection,  if repeat administrat...

From The Third International Symposium on Infectious Diseases of Bats in Ft. Collins, Colorado, TWiV speaks with Vincent Munster and Raina Plowright about their careers and their research on bats, bat viruses, bat ecology and spillover events. Hosts:  Vincent Racaniello and Brianne Barker Guests: Vincent Munster and Raina Plowright Subscribe (free):  Apple Podcasts ,  Google Podcasts ,  RSS ,  ema...

In his weekly clinical update Dr. Griffin discusses monkeypox infection in humans across 16 countries, pregnancy outcomes after SARS-CoV-2 infection by trimester, vaccination intent and belief, antiviral drug treatment for non-severe disease, the association of smoking with infected hospitalized patients, the association of Paxlovid on negative conversion rates among high-risk patients with COVID-...

From ASV 2022 in Madison, Wisconsin, TWiV speaks with Pamela Bjorkman and Andy Mehle about their careers and their research on influenza virus, HIV-1, SARS-CoV-2, and influenza virus. Hosts:  Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Guests: Pamela Bjorkman and Andy Mehle Subscribe (free):  Apple Podcasts ,  Google Podcasts ,  RSS ,  email Become a  patron  of TWiV! Li...

In COVID-19 clinical update #124, Dr. Griffin discusses the results of a variant vaccine booster trial, the neutralization of variant sub-lineages by Novavax, the CDC's recommendation of Novavax's COVID-19 vaccine in adults, Paxlovid in patients who are immunocompromised and hospitalized, and inhaled fluticasone for outpatient treatment. Subscribe (free):  Apple Podcasts ,  Google Podcasts ,  RSS...

TWiV reviews the FDA decision to update COVID-19 vaccine boosters in the fall, the meaning of fatigue with respect to long COVID, and a skin volatile induced by flavivirus reproduction that attracts mosquitoes to the infected host. Hosts:  Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free):  Apple Podcasts ,  Google Podcasts ,  RSS ,  email Become a  patron  of...

In COVID-19 clinical update #123, Dr. Griffin discusses rapid diagnostic testing in response to the monkeypox outbreak, leading causes of death in the US during the COVID-19 pandemic, antibody evasion by subvariants, broadly-neutralizing antibodies against emerging variants, factors associated with severe outcomes among hospitalized immunocompromised adults, measurement of the burden of hospitaliz...

Paul Offit returns to TWiV to discuss why, during the recent FDA advisory committee meeting, he voted against releasing revised COVID-19 vaccines containing an Omicron component, and the reasons why children must be vaccinated against the disease. Hosts:  Vincent Racaniello , Dickson Despommier , Rich Condit , and Kathy Spindler Guest: Paul Offit Subscribe (free):  Apple Podcasts ,  Google Podcast...

In COVID-19 clinical update #122, Dr. Griffin discusses vaccine availability and coverage among children, post-infection health impairments in children and adolescents, infection detection using salvia and nasopharyngeal samples, effectiveness of vaccines during delta dominance, durability of vaccine against severe outcomes, concern in the postvaccination era, infection rebound after Paxlovid & Mo...

TWiV discusses the recent decision by an FDA advisory committee to update COVID vaccines for the fall, the monkeypox virus outbreak, and the finding that enteric viruses infect the salivary glands and are transmitted through saliva. Hosts:  Vincent Racaniello , Dickson Despommier , Rich Condit , Kathy Spindler , and Brianne Barker. Subscribe (free):  Apple Podcasts ,  Google Podcasts ,  RSS ,  ema...

In COVID-19 clinical update #121, Dr. Griffin discusses age as a risk factor for severe disease, updated vaccine boosters for the fall, pediatric infection and antibody seroprevalence in Arkansas over the first year of the COVID-19 pandemic, all-cause maternal mortality in the United States before and during the pandemic, and the effect of 2-week interruption in methotrexate treatment and how it i...

TWiV explains the meaning of vaccine-derived poliovirus found in London sewage, risk of long COVID after infections with Delta or Omicron variants of SARS-CoV-2, and enhancers of innate immune signaling as broad-spectrum antivirals. Hosts:  Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler . Subscribe (free):  Apple Podcasts ,  Google Podcasts ,  RSS ,  email B...

In COVID-19 clinical update #120, Dr. Griffin discusses outcomes of SARS-CoV-2 reinfection, CDC recommendation for vaccines in young children, neurodevelopment outcomes in infants of mothers testing positive for COVID during pregnancy, efficacy of monoclonal antibodies and antivirals in hamsters, rebound phenomenon after PAXLOVID in high-risk persons, hospitalization for infection after PAXLOVID t...

TWiV provides an update on hepatitis of unknown etiology in children, an experimental nanoparticle vaccine for Epstein-Barr virus, and minimal impact of bamlanivimab therapy on antiviral antibodies induced by vaccination. Hosts:  Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free):  Apple Podcasts ,  Google Podcasts ,  RSS ,  email Become a  patron  of TWiV! Lin...

In COVID-19 clinical update #119, Dr. Griffin reviews tixagevimab for infection prevention, ivermectin for outpatient infection treatment, symptom rebound after PAXLOVID treatment, bamlanivimab minimally impacting immune response to vaccination, in-hospital mortality among infection patients, residual viral antigen in patients following infection, usage of Casirvimab/Imdevimab and Remdesivir in in...

From ASM Microbe 2022 in Washington DC, Vincent and Michael speak with science artists Michele Banks and Jane Hartman about their work and their inspiration. Hosts:  Vincent Racaniello and Michael Schmidt Guests: Michele Banks and Jane Hartman Subscribe (free):  Apple Podcasts ,  Google Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episode Trilobite Glassworks (Jane Hartman) A...

TWiV discusses the situation with monkeypox, risk factors for SARS-CoV-2 infections of cats and dogs, and a lineage-tracing mouse model for studying papillomavirus infections. Hosts:  Vincent Racaniello , Rich Condit , and Brianne Barker Subscribe (free):  Apple Podcasts ,  Google Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episode Monkeypox update (CDC) SARS-CoV-2 infection...