The Poison Lab

What substance could cause these symptoms? Send your guesses to Toxtalk1@gmail.com to participate in episode 10! A Morel Dilemma Support the show Review the show where ever your listening Get Messages from Toxo (Join the Newsletter!) Join as a supporting member Ad free episodes Bonus content and early access Discounts and give aways on GOTA PICCEM Mushroom card game The GOTTA PICCEM Poisonous Mush...

In this episode of toxicologist vs the internet Ryan Is joined by special guest Dr. Justin Corcoran, MD an emergency medicine physician and medical toxicologist. They take turns answering questions from reddit.com/r/askdrugs (the internet, really, really needs a toxicologist) and challenge each others toxic sleuthing by presenting cases of poisoning and allowing the other to determine the toxin re...

Ryan and Toxo dive in to Delta 8 THC, a new (maybe?) legal drug sweeping the U.S. Delta-8 THC: Key Resources and Studies New York Times Coverage Comprehensive article on Delta-8 THC, its growing popularity, and concerns: https://www.nytimes.com/2021/02/27/health/marijuana-hemp-delta-8-thc.html Studies of Delta-8 THC in Humans Systematic Review: Summarizes findings from a single key study on Delta-...

Case from the show https://pubmed.ncbi.nlm.nih.gov/22163140/ Mithradates https://www.wemjournal.org/article/S1080-6032(11)00043-3/pdf Case series on mad honey effects https://pubmed.ncbi.nlm.nih.gov/20575670/ Blog post on sodium channel openers https://emcrit.org/toxhound/ff-plant-sodium-channel-openers/ A Morel Dilemma Support the show Review the show where ever your listening Get Messages from T...

In this second rendition of toxicologist vs the internet Ryan Is joined by special guest Dr. Jillian Theobald, MD, PHD an emergency medicine physician and medical toxicologist. They take turns answering questions from reddit.com/r/askdrugs (the internet, really, really needs a toxicologist) and challenge each others toxic sleuthing by presenting cases of poisoning and allowing the other to determi...

Quick Review: Chloroquine and Hydroxychloroquine Toxicity Toxic Dose Chloroquine: >5 g is associated with severe toxicity (though toxicity can occur at lower doses). Hydroxychloroquine (HCQ): Toxic dose is less well-defined. Clinical Effects Seizures: Due to sodium channel blockade. Arrhythmias: Resulting from sodium channel blockade. Hypotension: Caused by alpha-adrenergic blockade. Hypokalemi...

In this episode Ryan and Toxo discuss some potential toxic spices and break down the toxicity and treatment of a once well known medicine Cinchona Bark, Quinine, and Associated Toxicities Historical Perspective Use of Cinchona Bark Powder for Malaria: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973170/ Evolutionary Pressure of Malaria on Sickle Cell Traits: https://www.ncbi.nlm.nih.gov/pmc/artic...

In this episode Ryan Is joined by a special guest Dr. Matthew Stanton PharmD, BCPS, DABAT, an emergency medicine pharmacist and clinical toxicologist. Ryan and Matt take turns answering questions from reddit.com/r/askdrugs (the internet, really, really needs a toxicologist) and finally they challenge each others toxic sleuthing by presenting some cases of poisoning and allowing the other to try to...

Action potential Sodium/Potassium ATPase pumps create more positively charged ions outside the cell than inside the cell, this creates a relative negative charge in the cell Phase 4- Resting (~ -90 mv) Phase 0- Sodium enters the cell (+10 mv)  Phase 1- Potassium efflux from cell as now there is no negative charge holding it in (0 mv)  Phase 2- Calcium channels open and allow calcium in,...

Great review of potential torsades mechanisms based off experimental data- https://www.sciencedirect.com/science/article/pii/S1880427611800050 A Morel Dilemma Support the show Review the show where ever your listening Get Messages from Toxo (Join the Newsletter!) Join as a supporting member Ad free episodes Bonus content and early access Discounts and give aways on GOTA PICCEM Mushroom card game T...

Ryan and Toxo go in depth on an old substance that has begun to resurface with new toxicity due to users taking massive amounts. Loperamide. Dive into the regulatory history, mechanisms of its toxic cardiac effects, and a brief discussion of treatment in episode 4. Buying as much loperamide as you possibly can  Loperamide History 1969 : Synthesized. (1) 1976 : FDA Approved as Schedule V. (2)...

Ryan and Toxo cover some topics off the "one pill can kill" list, try breaking down the toxic mechanism of opioid induced respiratory depression in a simplistic way (but maybe fail), and walk through the triage and management of poison center case where a child was "potentially" exposed to a lethal toxin at home. Case Report Pediatric ingestion case study discussed at the beginning of the episode:...

Get ready for a HEAVY subject, literally. Ryan and Toxo talk about the toxic mechanisms, signs of poisoning, and treatment of one of the worlds most ubiquitous poisons. This is a long, but interesting one, consider listening in chunks. Excellent Review Sources Calello DP, Henretig FM. "Lead." In: Goldfrank's Toxicologic Emergencies, 10th ed, Hoffman RS, Howland MA, Lewin NA, et al (Eds), McGraw Hi...

Concepts in this episode Ryan and Toxo introduce their roles while explaining the current state of toxicology and what exactly a poison is. testing our tests Sensitivity: Rate of Positive test in those who have the disease Specificity: Rate of negative test in those without the disease Positive predictive value: True positive/ True Positive + False Positive Negative predictive value: True negative...

Ryan and Toxo Discuss the History and Risks of a Common Disinfectant In this episode, Ryan and Toxo dive into the history of a commonly used disinfectant, exploring its dangers when misused. From creating chemical weapons to causing severe injuries, they break down its toxic potential and offer critical safety tips. They break down the many ways it can cause harm if not used appropriately, includi...

Ryan and Toxo introduce their roles while explaining the current state of toxicology and what exactly a poison is.   Information about medical and clinical toxicology can be found at  American Academy of Clinical Toxicology (AACT)- clintox.org American College of Medical Toxicology (ACMT)- acmt.net A Morel Dilemma Support the show Review the show where ever your listening Get Messages fr...

A Morel Dilemma Support the show Review the show where ever your listening Get Messages from Toxo (Join the Newsletter!) Join as a supporting member Ad free episodes Bonus content and early access Discounts and give aways on GOTA PICCEM Mushroom card game The GOTTA PICCEM Poisonous Mushroom Game! The Poisonus Fungus Amongus Children's Book! Full book reading (6 minutes!) Tox trinkets (Rep the show...