The Human Upgrade: Biohacking for Longevity & Performance

Your bloodwork looks normal. Your doctor says you’re fine. But you still feel exhausted, inflamed, anxious—or worse.   In this episode, Dave Asprey talks with  Dr. Daniel Pompa , a leading voice in  cellular detox and root-cause healing , to expose the hidden stressors hijacking your energy, hormones, and metabolism—even when your labs say you’re healthy.  Dr. Pompa shares his...

Most people run from stress. The world’s highest performers run toward it.   Sébastien Page manages over  $500 billion in global assets . He’s the CIO of one of the world’s largest investment firms, and he wrote  The Psychology of Leadership  while living under relentless pressure. His secret? He doesn’t avoid stress—he uses it as a tool for performance, clarity, and control.&n...

Your DNA, health data, and digital identity are encrypted, monetized, and weaponized against you.   But what if there was a way to take it back… and hack the system?  In this mind-expanding episode, Dave sits down with two elite hacker-founders— Michael Tiffany , CEO of  Fulcra.ai , and  Vishakh , founder of  Monadic DNA —to explore a radical shift in the way we store...

If your brain feels foggy, your mood swings like a pendulum, or your cravings seem to control you—this episode will flip what you think you know about your body and your mind. Because what if your thoughts… aren’t really yours?  In this mind-altering episode of  The Human Upgrade , Dr. Steven Gundry reveals a startling new theory: your gut microbiome might be controlling your thoughts. F...

If your hair is thinning, shedding, or simply not what it used to be—and nothing seems to work—this episode is for you. Because what if the story you’ve been told about balding… is wrong?  For decades, hair loss has felt like fate: genetic, inevitable, untouchable. But science is catching up to something deeper—something root-level. What if the real culprit behind age-related hair loss is cel...

What if you could rewrite the code of your personality—on command?  Not just  cope  with anxiety, overthinking, or social exhaustion… but  delete  the traits holding you back and install better ones?  This episode challenges everything you’ve been told about identity. Dave dives deep into the science of personality change to reveal why your habits, moods, triggers, an...

Your brain isn’t broken—it’s underpowered.  Energy crashes, poor sleep, brain fog, and emotional reactivity don’t just happen. You’re running on low voltage, and your mind pays the price.  In this episode, Dave sits down with  Dr. Patrick Porter , founder of BrainTap, to reveal how to  reprogram your brain using light, sound, and guided visualization —no substances, no side eff...

You think you’re helping your kid. You clear the path. You smooth the bumps. You make sure they never feel too sad, too bored, too uncomfortable.  It feels like love.  But what if it’s making them weak?  In this episode, Dave Asprey sits down with bestselling author, TED speaker, and resilience expert  Jennifer Cohen  to reveal how today’s parenting norms are quietly produ...

For decades, gut health was reduced to yogurt commercials and vague promises from probiotics that barely worked. But what if we’ve been targeting the wrong bugs, using the wrong delivery, and ignoring the true source of chronic inflammation and accelerated aging?  In this thought-provoking episode, Dave sits down with Hannah Kleinfeld, a leader in microbiome innovation, to expose why most pro...

For nearly a century, scientists believed we had discovered ALL of the essential fatty acids the human body needs. But what if they were wrong?  Stephanie Venn-Watson, a veterinary epidemiologist and longevity researcher, joins Dave to reveal a groundbreaking discovery— a newly identified essential fatty acid, C15,  that may hold the key to healthier aging and even longer lifespans. Orig...

You think you’re optimizing your brain—but what if the real culprit behind your brain fog, anxiety, and burnout is the modern world itself?  In this episode,  Columbia University psychiatrist and nutritional neuroscience pioneer  Dr. Drew Ramsey joins Dave Asprey to decode the biological chaos hijacking your mind—and how to fight back. From inflammation and gut dysbiosis to screen-i...

You think, you feel, you  are —but what if your consciousness isn’t just in your brain? What if reality itself is shaped by something beyond the physical?  In this episode,  Mark Gober—author, consciousness researcher, and former Silicon Valley banker—joins Dave Asprey  to challenge everything you think you know about the mind, reality, and human potential. He explores groundbr...

You hold the door open. You say yes when you mean no. You put others first—always. It feels like the right thing to do… but is it costing you more than you realize?  In this episode, Scott Barry Kaufman, Ph. D.—Columbia professor, psychologist, and author of Rise Above—joins Dave Asprey to expose the psychology of victim vs. empowerment mindsets . He reveals how toxic altruism, external valid...

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Your Brain is Lying to You—Here’s How to Take Back Control  Every day, your brain is running subconscious scripts—hidden mental loops that shape your decisions, habits, and even your self-worth. But what if those loops are sabotaging you?  In this episode,  Bizzie Gold , mind architect and creator of  The Break Method , joins Dave Asprey to expose the  self-deception patte...

Is the Way You Speak Limiting How You Think? For years, scientists debated how language shapes the brain, but new research reveals it goes far beyond communication. Some languages lack numbers, grammar, or even complex sentences—yet their speakers navigate reality in ways that defy expectations. In this mind-bending episode, linguist Daniel Everett, known for challenging Noam Chomsky’s theories, s...

For decades, we’ve been told that our DNA is a fixed blueprint—an unchangeable code that dictates our health and lifespan. But what if that’s only half the story?  Sharon Hausman-Cohen, a physician, researcher, and genomics expert at IntellxxDNA, joins Dave to reveal the cutting-edge science of  genetic optimization —how understanding your DNA can unlock  longer life, better brain f...

For years, we’ve been told that willpower and repetition are the keys to forming habits. But the truth is,  habits don’t stick because of repetition—they stick because of emotion!   In this all-time classic episode, Dave brings together two of the world’s top habit experts—BJ Fogg, PhD, and James Clear—to break down the real science of behavior change. BJ, the Stanford researcher behind&...

In this first-ever AMA episode, Dave tackles your biggest biohacking questions—straight from The Upgrade Collective ! From optimizing brain power to pushing the limits of cold therapy, this episode is packed with cutting-edge hacks to supercharge your body and mind. If you’d like to have your questions answered on the next AMA, click the link below for details on The Upgrade Collective m...

Can You Mimic Fasting—Without Actually Fasting?  Chris Rhodes, a biochemist and longevity researcher, joins Dave to reveal  a groundbreaking fasting mimetic  that could revolutionize how we approach aging, metabolism, and health.  Fasting is one of the most powerful tools for longevity, but what if you could achieve the same benefits without hunger, energy crashes, or social sa...

Could a single molecule be the difference between vibrant longevity and early decline?  Dr. Andrew Salzman—Harvard-trained physician, scientist, and creator of the first PARP1 inhibitor, Chief Medical Officer of Wonderfeel—joins Dave to reveal the  real  key to living longer, fighting disease, and maximizing your energy:  NAD.   This master molecule fuels your  mitoch...

Welcome to the metabolism masterclass! Dr. Ben Bikman (Ph. D Professor BYU), a powerhouse in metabolism science, joins Dave to expose the truth about  insulin resistance —the silent epidemic fueling obesity, chronic disease, and low energy. Forget the outdated calorie-counting nonsense (it doesn’t work)—Dr. Bikman reveals  how your hormones, not just your diet, control your metabolism &n...

Most people wait for inspiration. But what if you could train your brain to create on demand?   Rick Rubin has spent decades shaping the sound of legendary artists—Jay-Z, Johnny Cash, Metallica, and countless others—by tapping into the unseen forces of creativity. But what’s the secret behind his genius?  In this must-listen episode, Rick sits down with Dave to explore the  science...

What’s keeping you stuck in a scarcity mindset instead of stepping into abundance? What truly sets successful people apart from those who struggle?   Tony Robbins has spent decades answering these questions—coaching billionaires, world leaders, elite athletes, and everyday people to master their money, mindset, and mission. In this all-time classic podcast, he shares the hard-hitting truths a...

From chart-topping hits to life-threatening lows—how did Timbaland go from producing for Jay-Z, Beyoncé, and Justin Timberlake to battling addiction and obesity? And more importantly, how did he take his life back?   In this raw and revealing conversation, music icon Timbaland shares the blueprint behind his incredible transformation—how he broke free from opioid addiction, lost 130 pounds, a...