Nucleate Podcast

Follow us https://signal.nucleate.xyz/ Apply to the Entrepreneurial Fellows Program in Chicago with the CBC open from March 20-May 2,2025! https://chicagobiomedicalconsortium.org/awards/entrepreneurial-fellows/ In our latest podcast, hosted by Sam Kessel, Dr. Michelle Hoffmann discusses her unique journey from a PhD in molecular neuroscience PhD to a biotech consultant, and how her experiences sha...

Follow us on https://signal.nucleate.xyz/ 04:14 - Dr. Stehman-Breen discusses her decision to pursue a career in medicine. 05:49 - Dr. Stehman-Breen explains her specialty choice in internal medicine and nephrology. 08:09 - Skills and mindset that prepared Catherine for a career in industry. 13:53 - The critical impact that physicians can have in biotech 19:03 - Overview of epigenetic editing and...

Follow us at https://signal.nucleate.xyz/ 02:18 - Eric Kelsic's background in physics and systems biology and how it shaped his approach to biological problems 03:57 - Differences in problem-solving between Kelsic's physics/systems biology background and traditional biology backgrounds 06:27 - Learning from working with George Church and his lab's approach to fostering innovation 10:02 - George Ch...

Follow us on  https://signal.nucleate.xyz/ Peter Barrett discussed his career journey, from starting in a technical role at Perkin Elmer to co-founding Celera Genomics and being part of the team that first sequenced the human genome. He then transitioned to venture capital, joining Atlas Venture, where he has focused on building and investing in innovative therapeutic and drug discovery companies....

Follow the Nucleate Podcast on our website: https://signal.nucleate.xyz/ Jake Becraft, the co-founder and CEO of Strand Therapeutics, discusses his journey from pursuing a PhD in chemical engineering and synthetic biology at MIT to starting a biotech company focused on developing programmable mRNA therapeutics. At MIT, he worked on developing nanoparticles for DNA delivery and became interested in...

The Vagina Business, by Dr Marina Gerner, covers key issues in women's health and the novel solutions in development to address them. The book has already been getting attention with grants from the Alfred P. Sloan Foundation and The Society of Authors. Kirkus Reviews has praised the book as "energetic, thoroughly engaging reading" and emphasized its potential to improve women's health outcomes wo...

00:53 Michael discusses his background and inspirations for pursuing an intersectional career in biotech investing and film-making 6:24 Michael shares about taking time away from college to backpack in places like Fiji and New Zealand, and how that impacted his personal growth 12:43 Michael reflects on his experience at Pear Therapeutics, including lessons learned about business model risk and bri...

In this episode, Anastasia Janas interviews Leo Grady, founder and CEO of Jona. With over 20 years in AI and healthcare, Leo has made a profound impact on the field, including leading the development of the first FDA-approved AI system in pathology at Paige. AI. Together, they dive into the journey that led him to create Jona, a company focused on using AI to analyze the gut microbiome for persona...

In this episode, Sam Kessel and Anastasia Janas interview Luke Timmerman , an award-winning biotech journalist and founder of the Timmerman Report , as well as host of The Long Run Podcast . They explore Luke's non-traditional background, his curiosity, and his openness to learning, which shaped his journey to becoming a prominent figure in the biotech space. Luke shares insights into his career,...

In this episode, Sam Kessel speaks with Irene Blat, Senior Director for Search and Evaluation at Servier. Dr Blat discusses her lifelong fascination with science and inspiration to take her Oncology studies to industry to develop new therapies for patients. She discussed the intersection of science and business in Search and Evaluation identifying promising technologies. She talks about the key as...

0:00 Background and inspiration for pursuing a career in Biotech 5:10 Pivoting from academia to industry  8:30 Growth in industry from a scientist role into business development  16:15 The inspirational mission and vision for Bayer Co-lab to support early stage entrepreneurs 20:30 Fiona’s role at Bayer Co-lab 24:15 Fiona’s advice for entrepreneurs applying for the Co-lab 29:00 Fiona’s view on tren...

Part 2 Using TikTok to develop scientific communication skills [0:00] Advice for entrepreneurs starting a company [6:00] Guardian's Series A Fundraise and how they are navigating VC Fundraising [10:30] The long-term vision of Guardian Bio for novel cell therapies treating [14:30] The importance of Diversity in Biotech [17:20] Exciting trends in Biotech that Ananya and Ricky are following [25:40] P...

Origin Stories and path to Biotech [00:00] Taking the leap to entrepreneurship [07:30] The formation story of Guardian Bio [20:25] The methodical process Ananya used to identify a co-founder [26:00] The core thesis of Guardian Bio- Dendritic Cells for Solid Tumors [29:00] The key pivots Guardian made early on [34:15]

Check out Episode 8 of the Nucleate Podcast. We were honored to have Sean McClain, the founder and CEO of AbSci speak about generative AI for developing novel therapies. The potential to accelerate development of therapies for patients is astronomical.

[02:15] Bobby Gaspar’s background [05:10] The science of haematopoietic stem cell therapy [12:30] Spinning out Orchard Therapeutics [21:15] Reverse partnerships with pharma [25:55] Balancing regulatory compliance and innovation [29:45] Value based payments  [35:15] Recent approval of Casgevy and gene therapy regulation [39:45] Failures in a biotech’s journey [43:00] Impact and meaning in therapeut...

On this episode of the podcast, Signal hosts Michael Retchin and Ursule Demael interview Prof. Lee Cronin from Chemify. Lee Cronin is a Professor at the University of Glasgow, where he leads a research group focused on digital chemistry, automating chemical synthesis and origin of life. Lee Cronin is also the co-founder and CEO of Chemify, a startup advancing digitization and robotics for chemistr...

Trevor talks about his inspirations for his career path [1:22] How to choose his PhD advisor and lab [3:51] Career trajectory, handling moments of uncertainty, and learning from mistakes [9:56] Trevor discovered a niche at the intersection of biology, physics, and computer science [11:54] Mammoth is uniquely positioned as an innovative science-focused company that delivers for patients [18:36] Tre...

Show Notes Tony's career foundations as an academic scientist at MIT and early inspiration for entrepreneurship  [0:43] Engaging in entrepreneurial groups shaped Tony's early career [07:10] Tony's inspiration to co-found Petri [11:38] Pillar is rethinking the approach to biotech investing [25:21] Pillar's investment thesis [30:34] Tony's advice to a PhD student who is considering industry and entr...

What sparked Dr. Goodman’s interest in biotech (0:00) Deciding to pivot from academia to venture capital (3:45) Failing fast and applying that mindset to science (9:44) Transitioning from academia to a start up (14:44) Advice for aspiring technical founders (20:03) Becoming an investor at MPM Capital (30:24) MPM’s investment thesis in oncology. (40:14)

Introducing Nucleate Signal, a celebration of the next generation of biotech leaders. In this episode, host Emmanuella Nnuji-John is joined by guest Cheri Ackerman, the co-founder and CEO of Concerto Bioscience.

In this episode, host Jingyi Liu and Sam Kessel are joined by guest Martin-Immanuel Bittner, the co-founder and CEO of Arctoris.