Longevity Roadmap

Link to Buck's Results: https://drive.google.com/file/d/19BJaZNYwBxlPx4nR9695Q2NC3nNpgW6y/view?usp=sharing  https://drive.google.com/file/d/1br1ikAJKmgKev9X3jkS7nUPdXpAqMzYd/view?usp=sharing Section 1: Overview of Cholesterol Metabolism Cholesterol in the Body: Cholesterol is essential for cell membrane integrity, hormone synthesis, and bile acid production. It is produced endogenously in the live...

Buck shares his experience visiting a cardiologist and discusses his family history of heart disease. He explains the importance of coronary calcium CT scans and the significance of calcium scores. Buck also highlights the role of lipoprotein little a (Lp(a)) in cardiovascular disease and the potential for new medications to target and lower Lp(a) levels. He explores the use of low-dose colchicine...

This week's episode is about atherosclerosis, a condition that leads to cardiovascular disease. Buck explains the role of cholesterol and lipoproteins in the development of atherosclerosis. He emphasizes the importance of understanding this topic as cardiovascular disease is the leading cause of death. The conversation covers the different types of lipoproteins, such as HDL and LDL, and their asso...

Buck explains the difference between intermittent fasting and prolonged fasting, highlighting the benefits and potential pitfalls of each. 

Buck interviews Dr. Ken Frumkin on his own journey of aging and cognitive decline.

In this episode, Buck discusses gene editing and its potential implications for human health and longevity. He explains the basics of gene editing, including the structure of DNA and how genes are transcribed into proteins, then dives into the history and development of gene editing techniques, focusing on the game-changing CRISPR-Cas9 technology. He also explores the practical applications of gen...

Topics include: 00:25 Protein Intake for Longevity 12:40 Tips to Improve Sleep Quality 22:52 Is Robert F. Kennedy Jr. Controlled by a Worm

Topics include: 00:40 Is Weightloss Simply Calories In and Out? 07:10 Stem Cell Injections for NBA Players?   14:60 Statins for Lowering Cholesterol 23:19 The Impact of Nature and Nurture on Longevity

Buck Joffrey, MD discusses the concept of resilience with Stephen Sideroff, PhD. Topics include bouncing forward from stress and practical techniques to restore balance, nurture growth, and slow down the aging process. 01:35 Defining Resilience and the Ability to Adapt 08:21 Physical Balance and Mastery: Restoring Balance in the Nervous System 15:26 Self-Relationship: How It Changes Your Physiolog...

I've been hearing about stem cells for decades. When I was a medical student going into neurosurgery, I seriously considered focusing my research on neuroregeneration with stem cells. As it turns out, few advancements were made in that arena for many years until Hans Keirstead and his team did some groundbreaking work on quadriplegics.   Now Hans is focused on longevity. Hans may have found a new...

Buck discusses the concept of longevity clinics with the CEO of Humanaut. Show Notes: 03:53 What Does Humanaut Do? 06:07 The Team Behind Humanaut 14:49 How Does the Program Work?  

Buck Joffrey, MD reviews the literature on the topic of human attraction. Topics include the brain, perception of beauty, specific aspects of beauty, and sexual dimorphism. Also included is a discussion on the role of human pheromones and attraction. Show Notes: 01:20 Facial Attraction & Cues 08:30 Facial Symmetry 11:12 The Averageness of Facial Features 13:59 Clear and Unblemished Skin 15:44 Sexu...

Buck has a conversation with fellow physician, Dr. Matt Brill, on the topic of intermittent fasting. They bring up the American Heart Association study as well as associated studies of breakfast skippers to reconsider the issue of eight-hour time-restricted feeding. Also discussed are the topics of ideal, protein, intake, and full-body MRI. Show Notes: 01:33 8 Hours Or Less Fasting Window = Higher...

Buck Joffrey, MD discusses the basics of the keto diet with Amy Berger, a certified nutrition specialist. Topics include the definition of the diet, its health benefits and its role in the treatment of various disease processes including type 2 diabetes and Alzheimer's Disease. Show Notes: 03:08 Why the Keto Diet? 04:15 How Does the Keto Diet Help You Lose Weight? 05:51 Other Benefits of the Keto...

Buck Joffrey, MD reviews what is known about sexually transmitted cancers. Discussion includes HIV and Hepatitis but focuses on Human Papilloma Virus which Buck believes is grossly underappreciated by people and by physicians. 01:18 HIV 05:26 Hepatitis 09:20 HPV

Buck Joffrey, MD provides an introduction to the microbiome and discusses its importance. Topics also include prebiotics, probiotics, and postbiotics.

Buck Joffrey, MD, takes questions from the audience. Topics include human growth hormones, the potentially harmful effects of an MN, 40 Hz therapy, and visceral fat. Show Notes: 00:47 Is It Fine That I Sleep Too Much? 08:08 The 40hz Gamma Frequency and How It Relates to Brain Health 13:28 The Anti-Aging Effects of Human Growth Hormone 20:31 Reconsideration of How to Fast 29:22 Potentially Harmful...

Buck Joffrey, MD, discusses the fasting regimen with Dr. Valter Longo, PhD. Dr. Longo is a world, renowned researcher in longevity and the author of: The Longevity Diet. Show Notes:  01:10 Types of Fasting 03:31 Why Fasting is Beneficial From a Cellular Level 07:00 Intermittent Fasting VS Fast Mimicking Diet 14:05 How Does Fasting Help Cancer Patients 20:37 What Is in the Fast Mimicking Diet 33:38...

Buck Joffrey, MD interviews Robert Lufkin, MD about his book Lies I Taught in Medical School: And the Truths That Can Save Your Life Topics include metabolic syndrome, intermittent fasting, and various outdated information still used in mainstream medicine that may have deleterious effects on people's health. Show Notes: 01:35 Dr. Lufkin's Personal Journey to Question the Medicine Establishment 04...

Dr. Buck Joffrey, M.D. interviews, Dr. Nathan Price, PhD from Thorne about a new paradigm in medicine driven by data, technology, and self-empowerment. Show Notes: 00:58 What Really is Healthspan? 05:06 Biological Age VS Chronological Age 07:41 The Factors that Determine Biological Aging 12:08 What Happens When You Artificially Suppress These Factors 16:58 What is Phenomics and how can it predict...

In this April Fools special, Buck answers the burning questions of his number one fan, Phil Ferragamo.

In this episode of Sapio, Dr. Buck Joffrey, MD addresses the recent American Heart Association study correlating intermittent fasting/time restricted, feeding to higher rates of cardiovascular death. Buck breaks down what we already know about the data behind intermittent fasting in both animals and in humans and tries to put the most recent study into context. He provides feedback on the study it...

Buck Joffrey, MD talks to Romie Mushtaq, MD regarding stress, cortisol levels and prevention strategies including meditation and anti-inflammatory diets. Show Notes: 02:14 The definition of stress 13:16 Why does stress disrupt circadian rhythms and sleep 16:08 How do we treat stress? 21:23 Nootropics 24:39 Vagal nerve stimulator 28:34 Digital detox and meditation 33:02 Diet for stress  

Buck Joffrey MD speaks to Justin Houman MD who is a urologist regarding the idea of aggressive testosterone treatment to decrease the risk of metabolic syndrome and therefore multiple other disease processes that are downstream. Other topics disgust include erectile dysfunction, early treatment with ED meds and the correlation with Alzheimer's disease. Show Notes: 1:27 Is it true that the testoste...

Buck Joffrey, MD and Linda Tyler, PhD discuss the topic of plant-based only/Vegan diets. The conversation includes topics on inflammation and nutritional concerns. Show Notes: 2:55 A plant-based diet for better health? 11:53 Balancing nutritions for the plant-based diet 20:39 Accessibility of the plant-based diet 22:30 Processed plant-based food