Immune

The Immune trio explains how activation of the inflammasome by a bacterial protein causes blood clotting through a programmed cell death process called pyroptosis.   Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Inflammasome activation triggers blood clotting (Immunity) Rotavirus and Nlrp9b inflammasome (Nature) Societal Amnesia an...

The Immune team discusses immunization of pregnant mice to protect offspring from neonatal herpes simplex virus disease.   Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Maternal immunization protects offspring (Sci Trans Med) Diversity of herpesvirus in neonates ( TWiV 540 ) Mariana Mazzucato on Freakonomics Letters read on Immune...

The immunophiles discuss T cell antigen discovery by trogocytosis - the transfer of membrane patches among cells in close contact. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Trogocytosis for T cell antigen discovery (Nat Methods) Trogocytosis (J Immunol) Orphan T...

The immunophiles explain how metabolic rewiring of macrophages by CpG promotes clearance of cancer cells. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Become a  patron  of Immune! Links for this episode Darwin Day Metabolic rewiring of macrophages by CpG (Nat Immunol) Letters read on Immune 17 Time stamps by Jolene . Thanks! Weekly Science Picks Steph - Pregnant Scholar Cindy...

The Immune team turns to chickens, which have been important in understanding the immune system, to show that infection of mature B cells is not required for the pathogenesis of Marek's disease herpesvirus. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Subscribe (free):  iTunes , Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Role of B cell...

Stephanie takes the Immune team on a tour of neutrophils, the most abundant leukocytes in mammals, including tethers and slings, neutrophil rolling, and neutrophil nets. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Subscribe (free):  iTunes , Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Slings enable neutrophil rolling (Nature) Sling vid...

The Immune team explains the science behind the 2018 Nobel Prizes awarded to Allison and Honjo: checkpoint immunotherapy. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Subscribe (free):  iTunes , Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode 2018 Nobel Prize in Medicine 2018 Nobel Prize in Medicine ( pdf ) What's in a name? (Can Res Inst)...

The ImmuNerds discuss how a cellular long non-coding RNA binds to an innate RNA sensor and regulates virus-induced interferon production to prevent damage to the host. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Subscribe (free):  iTunes , Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Host lncRNA binds RIG-I (Cell) Microbe Art at virolog...

The Immune trifecta explores systems immunology, and its use in a study of immune system development in newborn children. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Become a  patron  of Immune! Links for this episode Immune system development in newborns (Cell) Dead parrots and live wildcats ( TWiV 185 ) Pathogenesis card game (JAMA) Letters read on Immune 12 Weekly Science...

Cindy and Vincent describe the construction of a gene network that programs mammalian cells to detect and eliminate bacterial infections. Hosts:  Vincent Racaniello  and Cynthia Leifer Become a  patron  of Immune! Links for this episode Immunomimetic designer cells (Cell) Antimicrobial drug resistance (NIH) Image credit Letters read on Immune 11 Science Picks Cindy - No Tdap link to autism Vincent...

The Immune team travels to the University of Maryland for ASV 2018, where they meet up with Rebecca Lynch to explore her work on broadly neutralizing antibodies against HIV-1. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Guest: Rebecca Lynch Become a  patron  of Immune! Links for this episode Lynch Laboratory Immune merchandise Image credit Music by Steve Neal . Immune logo i...

The Immune team explores the variable lymphocyte receptors of jawless vertebrates, a system of immunity that parallels the structurally unrelated antibodies of jawed vertebrates. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Become a  patron  of Immune! Links for this episode Lamprey VLR response to influenza virus (eLife) VLR-based immunity (Ann Rev Immunol) How the Immune Sy...

The Immune team reveals how γδ T cells that synthesize interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Become a  patron  of Immune! Links for this episode γδ17 T cells , T cell homeostasis and thermoregulation (Nat Immunol) γδ17 T cells cells at epithelial barriers (Nat Rev Immunol) Image credit Le...

The Immune hosts discuss how the complement system functions, and its role in early synapse loss in a mouse model of Alzheimer's disease. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Become a  patron  of Immune! Links for this episode Complement and microglia cause synapse loss in Alzheimer's (Science) Superresolution structured illumination microscopy Image credit Weekly Sci...

The Immune hosts explain how antibody molecules mature, then discuss the finding in infants of potent neutralizing antibodies against respiratory syncytial virus without somatic hypermutation. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Become a  patron  of Immune! Links for this episode Potent anti-RSV antibodies without somatic hypermutation (Immunity) History of vaccine e...

The ImmuoModulators provide a primer on mucosal defenses, and explain how sensitizing female mice to food allergens prevents allergic reactions in their offspring. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Become a  patron  of Immune! Links for this episode Food Allergy (Nat Rev Dis Prim) Maternal allergen sensitization (J Exp Med) Image credit Letters read on Immune #5 Mu...

The immu-knowledge-ists deconstruct the holy grail of oncologists, cancer immunotherapy, and the exciting development of CAR T cells and how they work. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Become a  patron  of Immune! Links for this episode Synthetic Immunoreceptors for Cancer Therapy (Trend Mol Med) Engineering immune cells to treat cancer (Cell) Engineering T cells...

Cindy, Steph, and Vincent discuss recent problems with dengue virus vaccine, and a bi-specific monoclonal antibody against Zika virus. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Become a  patron  of Immune! Links for this episode Model for dengue ADE (Scitable) Dengue ADE in humans (Science) Dengvaxia discussion ( TWiV 471 ) Bi-specific antibody to Zika virus (Cell) Buildin...

Cindy, Steph, and Vincent reveal that lymphocyte trafficking through lymph nodes and lymph are circadian - it is dependent on the time of day. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Become a  patron  of Immune! Links for this episode Circadian clocks control lymphocyte trafficking (Immunity) Lymph node image credit Letters read on Immune #2 Weekly Science Picks Cindy -...

Cindy, Steph, and Vincent launch a new podcast, Immune, and reveal how warm temperature protects against atherosclerosis by regulating monocyte migration into the blood. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Become a  patron  of Immune! Links for this episode Leifer Lab at Cornell Stephanie Langel Thermoneutrality suppresses monocyte egress from bone marrow (Circ Res)...