Basics to Brilliance: Haematology Podcast

Feedback CNS Lymphomas 1% of all NHL 3% of all Brain tumours Most common subtype (90%) is DLBCL   Clinical division: 1.  1* CNS lymphoma,  2.  2* CNS lymphoma - TN-SCNSL - RI-SCNSL - RC-SCNSL 3.  Immune deficiency assoc- HIV; better prog.   Presentation:  -    SOL Sx  -    Raised ICP: morning headaches w N+V -    Neuropsych, Behavioural, Memory, Language -    Focal motor + Stroke Sx -    Seizures...

Feedback   Chronic MyeloMonocytic Leukemia (not CML) Persistently high monocyte count- 3 months  Most frequent MDS/Myeloproliferative neoplasms – a cross between the two Median age 72 Median survival 20-40 months  Transformation to AML (15-30%)   WHO definition of CMML: 1. Excess monocytes- persistent over 3 months, ≥ 1                 - Monocytes 10% of total WC count 2. Dysplasia: morphological...

Feedback Chronic Lymphocytic Leukemia (CLL)- Chronic Relapsing Remitting Most  common leukemia in adults Incurable but treatable *Remember Supportive Care* Median age of 72 M > F 80% incidental SLL: lymphocytes in lymph nodes and spleen instead of blood  Presentation:  1) Fatigue 2) B symptoms 3) High WC 4) Cytopenias (Marrow infiltrate, AIHA, ITP, Hyposplenism) Rule out: Reactive (viral serolo...