Medical Digest & Congress Report

Doctor Brian M. Slomovitz presents Phase 3 KEYNOTE-C93/GOG-3064/ENGOT-en15 data evaluating first-line pembrolizumab monotherapy versus carboplatin plus paclitaxel in mismatch repair-deficient (dMMR) advanced or recurrent endometrial carcinoma at the ESMO Congress 2026. Video: https://medicaldigest.org/scientific-contents/interview:keynote-c93-first-line-pembrolizumab-vs-chemotherapy-dmmr-advanced-...

Doctor Hope S. Rugo presents results from the Phase 3 KEYNOTE-B49 study evaluating pembrolizumab versus placebo in combination with chemotherapy in patients with HR+/HER2− advanced breast cancer at the ESMO Congress 2026. Video: https://medicaldigest.org/scientific-contents/interview:keynote-b49-pembrolizumab-plus-chemotherapy-hrher2-advanced-breast-cancer

Professor Hope S. Rugo discusses key advances, targeted systemic options, and novel treatment strategies in managing brain metastases in patients with metastatic breast cancer at the ESMO Congress 2026. Video: https://medicaldigest.org/scientific-contents/interview:advances-brain-metastases-management-breast-cancer

Doctor Jacob Sands presents primary analysis data from the Phase 3 DeLLphi-305 trial, evaluating tarlatamab plus durvalumab versus durvalumab alone as first-line maintenance therapy for patients with extensive-stage small cell lung cancer (ES-SCLC) at the ESMO Congress 2026. Video: https://medicaldigest.org/scientific-contents/interview:available-research-guiding-selection-therapy-patients-chronic...

Professor Karijn Suijkerbuijk summarizes the most important practice-changing trials, therapeutic updates, and clinical highlights in melanoma and other skin tumours presented at the ESMO Congress 2026. Video: https://medicaldigest.org/scientific-contents/interview:melanoma-and-skin-tumours-highlights-esmo-2026

Professor Julien Taieb highlights key therapeutic novelties, emerging clinical trial results, and evolving treatment paradigms in colon cancer presented at the ESMO Congress 2026. Video: https://medicaldigest.org/scientific-contents/interview:novelties-treatment-colon-cancer-esmo-2026

Terri D. Conneran shares a powerful patient perspective on living with KRAS-mutated lung cancer and advancing the frontiers of patient-centric care at the ESMO Congress 2026. For more information and resources, visit the KRAS Kickers website. Video: https://medicaldigest.org/scientific-contents/interview:patient-perspective-living-kras-mutated-lung-cancer

Professor Georgina V. Long presents the Phase III INTerpath-001 trial results evaluating the mRNA-based individualized neoantigen therapy intismeran autogene in combination with pembrolizumab versus pembrolizumab alone as adjuvant treatment for patients with resected stage IIB–IV melanoma at the ESMO Congress 2026. Video: https://medicaldigest.org/scientific-contents/interview:interpath-001-adjuva...

Professor Amanda Psyrri summarizes the most important practice-changing trial results, emerging biomarker data, and therapeutic advances in head and neck cancer presented at the ESMO Congress 2026. Video: https://medicaldigest.org/scientific-contents/interview:head-and-neck-cancer-highlights-esmo-2026

Professor Kohei Shitara discusses key findings from two pivotal late-breaking trials in gastroesophageal cancer presented at the ESMO Congress 2026: the HERIZON-GEA-01 study and the CLARITY-Gastric 01 trial. Video: https://medicaldigest.org/scientific-contents/interview:key-clinical-updates-gastroesophageal-cancer-herizon-gea-01-and-clarity-gastric-01

Doctor Kohei Shitara highlights key advances in clinical practice, evolving therapeutic strategies, and patient care management in gastroesophageal cancer at the ESMO Congress 2026. Video: https://medicaldigest.org/scientific-contents/interview:advancing-clinical-practice-and-patient-care-gastroesophageal-cancer

Professor Alessandra Gennari summarizes the key practice-changing trials, biomarker advances, and clinical highlights in breast cancer presented at the ESMO Congress 2026. Video: https://medicaldigest.org/scientific-contents/interview:breast-cancer-highlights-esmo-2026

Professor Ferdinandos Skoulidis presents the landmark Phase III KRASCENDO-1 study results evaluating the efficacy and safety of divarasib versus standard-of-care sotorasib or adagrasib in previously treated locally advanced or metastatic KRAS G12C-mutated non-small cell lung cancer (NSCLC) at the ESMO Congress 2026. Video: https://medicaldigest.org/scientific-contents/interview:krascendo-1-divaras...

Doctor Vishal A. Patel discusses reshaping adjuvant and perioperative strategies in cutaneous squamous cell carcinoma (CSCC), highlighting the integration of surgery, radiation, and systemic therapies through multidisciplinary decision-making at the ESMO Congress 2026. Video: https://medicaldigest.org/scientific-contents/interview:reshaping-adjuvant-and-perioperative-strategies-cscc

Doctor Alice Bernard-Tessier discusses the critical importance of selecting the optimal first-line treatment at the earliest opportunity for patients with advanced prostate cancer at the ESMO Congress 2026. Video: https://medicaldigest.org/scientific-contents/interview:why-first-choice-matters-optimising-frontline-therapy-advanced-prostate-cancer

Professor William J. Gradishar summarizes key clinical data, treatment strategies, and the evolving role of sacituzumab govitecan in triple-negative breast cancer (TNBC) at the ESMO Congress 2026. Video: https://medicaldigest.org/scientific-contents/interview:sacituzumab-govitecan-triple-negative-breast-cancer

Professor William J. Gradishar discusses key findings and clinical highlights from the advanced breast cancer Rapid Oral session at the ESMO Congress 2026. Video: https://medicaldigest.org/scientific-contents/interview:key-updates-advanced-breast-cancer

Prof. Evelien Dekker highlights key updates in screening and surveillance protocols for colorectal cancer prevention at the UEG Week 2026 Congress. This brief examines the practical application of the new European guidelines, discussing evidence-based recommendations to optimize risk stratification, refine post-polypectomy surveillance, and enhance quality standards in clinical practice to reduce...

Dr. David Martí-Aguado addresses the clinical challenges surrounding metabolic dysfunction-associated steatohepatitis (MASH) and progressive liver fibrosis at the UEG Week 2026 Congress. This brief outlines the expanding burden of MASH in gastroenterology practice, emphasizing early risk stratification, non-invasive diagnostic strategies, and the emergence of targeted disease-modifying therapies d...

Dr. Naim Alkhouri highlights the critical central role of the liver in cardiometabolic health at the UEG Week 2026 Congress. This brief explores the complex intersections between obesity, metabolic dysfunction-associated steatotic liver disease (MASLD), and MASH, providing gastroenterologists with actionable strategies for early identification, integrated care workflows, and modern therapeutic opt...

Dr. Christopher Ma presents actionable insights on advancing clinical care in Crohn’s disease at the UEG Week 2026 Congress. This brief explores updated management algorithms, emphasizing risk stratification, proactive monitoring, and timely optimization of biologic and novel targeted therapies to achieve durable disease control and improve long-term outcomes for patients with Crohn's disease....

Dr. Manuel Barreiro de Acosta shares key perspectives on navigating the modern therapeutic landscape in ulcerative colitis at the UEG Week 2026 Congress. Focusing on the IL-23 pathway, this brief highlights clinical data and strategic considerations for incorporating IL-23 targeted therapies to achieve durable endoscopic remission and set new standards in patient-centered IBD care. Video: https://...

Prof. Remo Panaccione highlights modern therapeutic strategies in inflammatory bowel disease at the UEG Week 2026 Congress. This brief examines the evolving roles of advanced targeted agents, focusing on the clinical utility of novel JAK inhibitors and IL-23 targeted therapies to achieve deep disease control, optimize long-term patient outcomes, and personalize treatment pathways in IBD. Video: ht...

Prof. Jean-Frédéric Colombel presents key insights on optimizing therapeutic outcomes in ulcerative colitis at the UEG Week 2026 Congress. Drawing from the latest data from the VERDICT trial, this brief explores the clinical rationale for targeting deep endoscopic and histological healing, highlighting strategies to elevate treatment standards, prevent long-term bowel damage, and achieve sustained...

Dr. Caterina Conte presents key takeaways from the EASD e-Learning expert session on obesity at the EASD 2026 Congress. This brief highlights clinical strategies for comprehensive weight management, addressing metabolic comorbidities, and utilizing evidence-based educational frameworks to optimize patient care. Video: https://medicaldigest.org/scientific-contents/interview:easd-e-learning-expert-s...